E. Cheng

Kinome focused CRISPR-Cas9 screens in African ancestry patient-derived breast cancer organoids identifies essential kinases and synergy of EGFR and FGFR1 inhibition.

The paper uses CRISPR-Cas9 screens in breast cancer organoids from African ancestry patients to identify essential kinases and show synergy between EGFR and FGFR1 inhibitors.

Patient-derived tumor organoids with p53 mutations, and not wild-type p53, are sensitive to synergistic combination PARP inhibitor treatment

This study shows that tumor organoids with mutant p53 are more sensitive to the combination of PARP inhibitor and temozolomide than those with wild-type p53.

A comprehensive phenotypic screening strategy to identify modulators of cargo translocation by the bacterial Type IVB secretion system

This paper identifies compounds that inhibit T4SS-mediated effector delivery in pathogens, offering potential for pathogen-specific therapeutics.

Assignment of structural transitions during mechanical unwrapping of nucleosomes and their disassembly products

This study uses optical tweezers and FRET to identify DNA segments unwrapped during nucleosome mechanical transitions, revealing distinct low- and high-force unwrapping processes.

Spatial positioning and matrix programs of cancer-associated fibroblasts promote T cell exclusion in human lung tumors

The paper identifies two CAF subsets in human lung tumors that promote T cell exclusion through distinct matrix programs and spatial organization.

Sensitive detection of highly fragmented cytomegalovirus nucleic acid in human cfDNA

The paper detects highly fragmented CMV nucleic acid in maternal cfDNA and shows its distinct fragment length distribution compared to human cfDNA, which may explain discrepancies in qPCR measurements.