Author

A. Lerch

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Assay:DNA methylation· 2 Approach:experimental assay· 2 Assay:metagenomics· 2 Organism:plant (other)· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1

Frequent Co-Authors

C. Koepfli· 3 shared I. Felger· 3 shared I. Mueller· 3 shared I. Betuela· 2 shared J. H. Kattenberg· 2 shared A. Jex· 1 shared A. Rosanas-Urgell· 1 shared B. Ansell· 1 shared

Activity by Year

2017-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersMicrobiology

C. Koepfli

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Author profile →

4 papers

Recent·Most cited

Should deep-sequenced amplicons become the new gold-standard for analysing malaria drug clinical trials?

S. Jones, K. Kay, E. M. Hodel, M. Gruenberg, A. Lerch, I. Felger, I. Hastings

This paper evaluates deep sequenced amplicons (AmpSeq) as a method for molecular correction in malaria drug trials, finding it improves drug failure rate detection compared to current methods.

bioRxiv · Mar 23, 2021Microbiology

Transcriptome and histone epigenome of Plasmodium vivax salivary-gland sporozoites point to tight regulatory control and potential mechanisms for liver-stage differentiation.

A. Jex, I. Mueller, S. Kappe, S. Mikolajcjak, J. Sattabongkot, R. Patrapuvich, S. Lindner, E. Flannery, C. Koepfli, B. Ansell, A. Lerch, K. E. Swearingen, S. J. Emery-Corbin, S. Charnaud, J. Smith, , V. Chuenchob

This study characterizes the transcriptome and histone epigenome of Plasmodium vivax sporozoites, revealing transcriptional and post-transcriptional control mechanisms and potential pathways for hypnozoite formation.

bioRxiv · Dec 3, 2018 · PreprintMicrobiology

Longitudinal tracking of Plasmodium falciparum clones in complex infections by amplicon deep sequencing

A. Lerch, C. Koepfli, N. E. Hofmann, J. H. Kattenberg, A. Rosanas-Urgell, I. Betuela, I. Mueller, I. Felger

This study compares Amp-Seq and length-polymorphism genotyping for tracking Plasmodium falciparum clones in longitudinal infections, finding Amp-Seq more sensitive for detecting minority clones.

bioRxiv · Apr 30, 2018Microbiology

Development Of Amplicon Deep Sequencing Markers And Data Analysis Pipeline For Genotyping Multi-Clonal Malaria Infections

A. Lerch, C. Koepfli, N. Hofmann, C. Messerli, S. Wilcox, J. H. Kattenberg, I. Betuela, L. O'Connor, I. Mueller, I. Felger

The paper develops amplicon deep sequencing markers and a pipeline for genotyping multi-clonal malaria infections, showing improved sensitivity for detecting minority clones.

bioRxiv · Apr 3, 2017Microbiology