K. Kay

γ-aminobutyric acid receptor B signaling drives glioblastoma in females in an immune-dependent manner

This study shows GABA receptor B signaling promotes GBM growth in females through immune mechanisms, with sex-specific effects on survival and treatment outcomes.

Tumor cell-derived spermidine promotes a pro-tumorigenic immune microenvironment in glioblastoma via CD8+ T cell inhibition

This study shows that spermidine, a metabolite from glioblastoma cells, suppresses CD8+ T cell function, promoting tumor growth and poor patient outcomes.

Distinct cell adhesion signature defines glioblastoma myeloid-derived suppressor cell subsets

The paper identifies distinct cell adhesion signatures in glioblastoma myeloid-derived suppressor cell subsets, showing that monocytic MDSCs drive tumor growth through enhanced integrin β1 expression.

WDR5 represents a therapeutically exploitable target for cancer stem cells in glioblastoma

This study identifies WDR5 as an essential epigenetic regulator in therapy-resistant glioblastoma cancer stem cells and shows that WDR5 inhibitors disrupt CSC maintenance and tumor growth.

Should deep-sequenced amplicons become the new gold-standard for analysing malaria drug clinical trials?

This paper evaluates deep sequenced amplicons (AmpSeq) as a method for molecular correction in malaria drug trials, finding it improves drug failure rate detection compared to current methods.

Linking mountaintop removal mining to water quality for imperiled species using satellite data

The paper links mountaintop removal mining to water quality degradation in streams critical for imperiled species using satellite data and water quality monitoring.

Evaluating artesunate-amodiaquine deployment, efficacy and safety: an in silico pharmacological model

This study uses a pharmacological model to compare the efficacy, effectiveness, and safety of AS-AQ fixed dose combination and non-fixed formulations in different treatment scenarios.