Transcriptome and histone epigenome of Plasmodium vivax salivary-gland sporozoites point to tight regulatory control and potential mechanisms for liver-stage differentiation.
A. Jex, I. Mueller, S. Kappe, S. Mikolajcjak, J. Sattabongkot, R. Patrapuvich, S. Lindner, E. Flannery, C. Koepfli, B. Ansell, A. Lerch, K. E. Swearingen, S. J. Emery-Corbin, S. Charnaud, J. Smith, , V. Chuenchob
This study characterizes the transcriptome and histone epigenome of Plasmodium vivax sporozoites, revealing transcriptional and post-transcriptional control mechanisms and potential pathways for hypnozoite formation.
bioRxiv · Dec 3, 2018 · PreprintMicrobiology