Author

A. Lesage

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Physiology· 2

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Research Focus:cell type annotation· 2 Assay:electrophysiology· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

C. Marionneau· 3 shared M. Lorenzini· 3 shared D. Maloney· 2 shared J. M. Nerbonne· 2 shared M. Barbi· 2 shared R. R. Townsend· 2 shared S. Burel· 2 shared B. Evrard· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersPhysiology

C. Marionneau

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Author profile →

5 papers

Recent·Most cited

FHF2 phosphorylation and regulation of native myocardial NaV1.5 channels

A. Lesage, M. Lorenzini, S. Burel, M. Sarlandie, F. Bibault, D. Maloney, J. Silva, R. R. Townsend, J. M. Nerbonne, C. Marionneau

This study identifies phosphorylation sites on FHF2 in mouse NaV1.5 channels and shows differential regulation of neonatal and adult ventricular NaV1.5 by FHF2 phosphorylation.

bioRxiv · Jan 31, 2023Physiology

Assessing the polymer coil-globule state from the very first spectral modes

T. Földes, A. Lesage, M. Barbi

This paper introduces a method to determine the coil-globule state of a polymer using only the first two Rouse modes, without requiring polymer length or interaction strength information.

bioRxiv · Jul 17, 2021Biophysics

Proteomic and functional mapping of cardiac NaV1.5 channel phosphorylation reveals multisite regulation of surface expression and gating

M. Lorenzini, S. Burel, A. Lesage, E. Wagner, C. Charriere, P.-M. Chevillard, B. Evrard, D. Maloney, K. M. Ruff, R. V. Pappu, S. Wagner, J. M. Nerbonne, J. R. Silva, R. R. Townsend, L. S. Maier, C. Marionneau

The paper identifies 42 phosphorylation sites on NaV1.5 channels in mouse hearts and shows their roles in regulating channel expression and gating.

bioRxiv · Apr 29, 2020Physiology

Computer modeling of whole-cell voltage-clamp analyses to delineate guidelines for good practice of manual and automated patch-clamp

J. Montnach, M. Lorenzini, A. Lesage, I. Simon, S. Nicolas, E. Moreau, C. Marionneau, I. Baro, M. De Waard, G. Loussouarn

The paper uses computational models to establish guidelines for optimal current amplitude settings in whole-cell voltage-clamp recordings to improve accuracy in ion channel characterization.

bioRxiv · Apr 27, 2020Biophysics

Polymer coil-globule phase transition is a universal folding principle of Drosophila epigenetic domains

A. Lesage, V. Dahirel, J.-M. Victor, M. Barbi

The paper analyzes super-resolution data of Drosophila chromatin domains to show they follow polymer coil-globule transitions, with different epigenetic states corresponding to distinct structural behaviors.

bioRxiv · Apr 19, 2019Biophysics