Paradoxical role of AT-rich interactive domain 1A in restraining pancreatic carcinogenesis
S. Ferri-Borgogno, S. Barui, A. M. McGee, T. Griffiths, P. K. Singh, C. G. Piett, B. Ghosh, S. Bhattacharyya, A. Singhi, K. Pradhan, A. Verma, Z. Nagel, A. Maitra, S. Gupta
This study investigates the role of Arid1a in pancreatic carcinogenesis using mouse models and cell lines, finding that its loss impairs tumor growth and DNA repair but allows for later aggressive cancer development.
bioRxiv · Nov 8, 2019Cancer Biology