Author

A. Singhi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Pathology· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 5 Approach:experimental assay· 4 Research Focus:cancer & tumor microenvironment· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:development & morphogenesis· 2 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

A. Bell· 3 shared J. Tao· 3 shared K. Nejak-Bowen· 3 shared M. Poddar· 3 shared S. Hu· 3 shared S. ko· 3 shared S. Singh· 3 shared L. M. Molina· 2 shared

Activity by Year

2018-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersPathology

A. Bell

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

β-Catenin-NFκB-CFTR interactions in cholangiocytes regulate inflammation and fibrosis during ductular reaction

S. Hu, J. Russell, S. Liu, R. Rai, K. Kosar, J. Tao, E. Hurley, M. Poddar, S. Singh, A. Bell, D. Shin, R. Raeman, A. Singhi, K. Nejak-Bowen, S. ko, S. P Monga

This study identifies a β-catenin-NFκB-CFTR interactome in cholangiocytes that regulates inflammation and fibrosis during ductular reaction in liver disease.

eLife · Oct 5, 2021Peer-reviewedPathology

NOTCH-YAP1/TEAD-DNMT1 axis regulates hepatocytereprogramming into intrahepatic cholangiocarcinoma

S. Hu, L. M. Molina, J. Tao, S. Liu, M. Hassan, S. Singh, M. Poddar, A. Bell, D. Sia, M. Oertel, R. Raeman, K. Nejak-Bowen, A. Singhi, J. Luo, S. P. Monga, S. Ko

The paper identifies a NOTCH-YAP1/TEAD-DNMT1 axis that drives hepatocyte reprogramming into intrahepatic cholangiocarcinoma and reveals its role in tumor development.

bioRxiv · Dec 3, 2020 · PreprintCancer Biology

Compensatory hepatic adaptation accompanies permanent absence of intrahepatic biliary network due to YAP1 loss in liver progenitors

L. M. Molina, J. Zhu, Q. Li, T. Pradhan-Sundd, K. Sayed, N. Jenkins, R. Vats, S. Ko, S. Hu, M. Poddar, S. Singh, J. Tao, P. Sundd, A. Singhi, S. C. Watkins, , S. P. Monga

This study shows YAP1 is essential for bile duct development and reveals hepatocyte adaptation in its absence.

bioRxiv · Oct 21, 2020Pathology

Detection of Chemotherapy-Resistant Pancreatic Cancer Using a Glycan Biomarker

C. Gao, L. Wisniewski, Y. Liu, B. Staal, I. Beddows, D. Plenker, M. Aldakkak, J. Hall, D. Barnett, M. Kheir Gouda, P. Allen, R. Drake, A. Zureikat, Y. Huang, D. Evans, , B. Haab

This paper identifies sTRA as a glycan biomarker for chemotherapy-resistant pancreatic cancer, showing its presence correlates with poor treatment response in multiple systems.

bioRxiv · Jun 1, 2020 · PreprintCancer Biology

Paradoxical role of AT-rich interactive domain 1A in restraining pancreatic carcinogenesis

S. Ferri-Borgogno, S. Barui, A. M. McGee, T. Griffiths, P. K. Singh, C. G. Piett, B. Ghosh, S. Bhattacharyya, A. Singhi, K. Pradhan, A. Verma, Z. Nagel, A. Maitra, S. Gupta

This study investigates the role of Arid1a in pancreatic carcinogenesis using mouse models and cell lines, finding that its loss impairs tumor growth and DNA repair but allows for later aggressive cancer development.

bioRxiv · Nov 8, 2019Cancer Biology

Petite Integration Factor 1 (PIF1) helicase deficiency increases weight gain in Western diet-fed female mice without increased inflammatory markers or decreased glucose clearance

B. A. Kaufman, F. Belmonte, N. Dedousis, I. Sipula, N. Desai, A. Singhi, y. chu, Y. Zhang, S. Bannwarth, V. Paquis-Flucklinger, L. Harrington, R. M. O'Doherty, M. J. Jurczak

This study shows that PIF1 helicase deficiency in female mice on a Western diet leads to increased weight gain but not inflammation or reduced glucose clearance.

bioRxiv · Aug 16, 2018Physiology