A. M. Nicola

This paper investigates how the constant region, specifically the hinge, influences antigen binding in murine IgG antibodies targeting Cryptococcus neoformans capsule polysaccharides, showing that the hinge is necessary but not sufficient for binding differences between isotypes.

This study investigates the role of LC3-associated phagocytosis in macrophage response to Paracoccidioides spp., finding that autophagy is important for antifungal activity and that signaling pathways differ from other fungi.

The paper generates a monoclonal antibody against HSP90 in Paracoccidioides fungi that opsonizes fungal cells and enhances macrophage uptake, suggesting potential for immunotherapy.

This study shows that faster melanization in Cryptococcus species correlates with increased virulence and worse patient outcomes.

This study shows that soil amoebae interact with Paracoccidioides spp., increasing fungal virulence through the accumulation of cell wall alpha-glucans.

This study develops a method to observe Cryptococcus neoformans capsule dynamics in real-time without opsonins, revealing capsule distribution during budding.