J. R. Byrnes

This paper optimizes a high-resolution proximity labeling method to identify protein partners of HER2 on cells and in vitro, finding 20 high-confidence neighbors enriched compared to non-specific labeling.

This paper introduces two methods for rapid, small-scale cell surface biotinylation using tethered enzymes, enabling surface proteome analysis of cells and exosomes with high coverage and quantification of 1,020 surface proteins.

This study compares how hypoxia and regulatory T cells affect the CD8+ T cell surface proteome, finding hypoxia has a more significant impact than Treg-mediated suppression.

This paper identifies and engineers multivalent human VH domains that neutralize SARS-CoV-2 by targeting distinct epitopes on the Spike protein's ACE2 binding interface, showing increased affinity and potency.

The paper develops a method to capture and sequence cell surface N termini in live cells, revealing changes in neo-N termini abundance in response to proteolytic stimuli.