Q. Yao

Un1Cas12f1 and Cas9 gene drive in HSV1: Viruses that 'infect' viruses

This study develops Cas9 and Un1Cas12f1 gene drives in HSV1 to assess gene drive efficacy and resistance, finding Un1Cas12f1 has higher conversion and lower resistance.

Kindlin-2 inhibits TNF/NF-kB-caspase 8 pathway in hepatocytes to maintain liver development and function

This study shows Kindlin-2 inhibits the TNF/NF-kB-caspase 8 pathway in hepatocytes, preventing liver fibrosis and dysfunction, and identifies it as a potential therapeutic target for liver diseases.

Multiomics reveal that silk fibroin and sericin differentially potentiate the paracrine functions of mesenchymal stem cells and enhance tissue regeneration

This study uses multiomics to show that silk fibroin and sericin enhance mesenchymal stem cell paracrine activity and tissue regeneration through distinct pathways.

Species existence and coexistence under nutrient enrichment in the Park Grass

The paper uses long-term experimental data to test hypotheses about plant diversity loss under nutrient enrichment, finding support for competitive asymmetry and soil acidification over niche dimension.

Quality Control Framework of TCM Preparations based on Multi-type Fingerprints using a Source Proportion Estimation Model

This paper proposes a quality control framework for TCM preparations using multi-type fingerprints and a source proportion estimation model to evaluate batch consistency and manufacturer differences.

A novel widespread bacterial structure related to the flagellar type III secretion system

The paper identifies a novel widespread bacterial structure related to the flagellar type III secretion system, suggesting its involvement in diverse cellular functions.

Human Taste Cells Express ACE2: A Portal for SARS-CoV-2 Infection

This study shows that SARS-CoV-2 replicates in taste Type II cells expressing ACE2, leading to disrupted stem cell turnover in taste papillae of infected patients.

Human fecal microbiota is associated with colorectal cancer

This study analyzes fecal microbiota composition in CRC patients and identifies Fusobacterium as a potential biomarker for CRC screening in Chinese populations.

Detection of melanin-mediated false-positive for BaxΔ2 immunohistochemical staining in human skin tissue

The paper identifies that melanin in skin tissue causes false-positive BaxΔ2 immunostaining in the epidermis, but not in dermal connective tissues.

Challenges in solving structures from radiation-damaged tomograms of protein nanocrystals assessed by simulation

This paper evaluates a data processing pipeline for solving protein structures from radiation-damaged tomograms of nanocrystals using simulations.

Meta-16S rRNA gene phylogenetic reconstruction reveals astonishing diversity of the cosmopolitan myxobacteria

The paper analyzes 4997 16S rRNA gene sequences to reveal high taxonomic diversity and cosmopolitan distribution of myxobacteria, with many uncultured taxa and habitat-specific preferences.

Bacterial swarming reduces Proteus mirabilis and Vibrio parahaemolyticus cell stiffness and increases β-lactam susceptibility

Fusion of DARPin to aldolase enables visualization of small protein by cryoEM

The paper describes a platform using DARPin fused to aldolase to visualize small proteins by cryoEM, achieving 5-8 Å resolution for GFP.

Simulations suggest a constrictive force is required for Gram-negative bacterial cell division

The paper uses simulations to show that a constrictive force is needed for Gram-negative bacterial cell division, as cell wall remodeling alone is insufficient.

FtsEX-Mediated Regulation Of Inner Membrane Fusion And Cell Separation Reveals Morphogenetic Plasticity In Caulobacter crescentus

This study shows that FtsEX regulates cytokinesis in Caulobacter crescentus, revealing morphogenetic plasticity where loss of FtsE leads to stalk-like structures at failed division sites.