PhysiologybioRxivPreprint
Late life metformin treatment limits cell survival and shortens lifespan by triggering an aging-associated failure of energy metabolism.
L. Espada, A. Dakhovnik, P. S. Chaudhari…·M. Ermolaeva
This study shows that late-life metformin treatment reduces cell survival and lifespan by impairing energy metabolism, contrasting its beneficial effects in early life.
DOI 10.1101/863357