Author

L. Espada

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Organism:human· 2 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

A. Dakhovnik· 1 shared A. Koeberle· 1 shared A. Martirosyan· 1 shared A. Nair· 1 shared A. Ori· 1 shared C. Breunig· 1 shared G. Esposito· 1 shared H.-P. Holthoff· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperPhysiology

A. Dakhovnik

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Nanobodies against SARS-CoV-2 non-structural protein Nsp9 inhibit viral replication by targeting innate immunity

T. Venit, J. Blavier, S. B. Maseko, S. Shu, L. Espada, C. Breunig, H.-P. Holthoff, S. C. Desbordes, M. Lohse, G. Esposito, J.-C. Twizere, P. Percipalle

This paper designs nanobodies against SARS-CoV-2 Nsp9 to inhibit viral replication, showing effectiveness against multiple variants in HEK293-ACE2 cells.

bioRxiv · Oct 12, 2023 · PreprintCell Biology

Late life metformin treatment limits cell survival and shortens lifespan by triggering an aging-associated failure of energy metabolism.

L. Espada, A. Dakhovnik, P. S. Chaudhari, A. Martirosyan, L. Miek, T. Poliezhaieva, Y. Schaub, A. Nair, N. Doering, N. Rahnis, O. Werz, A. Koeberle, J. Kirkpatrick, A. Ori, M. Ermolaeva

This study shows that late-life metformin treatment reduces cell survival and lifespan by impairing energy metabolism, contrasting its beneficial effects in early life.

bioRxiv · Dec 3, 2019 · PreprintPhysiology