J. Kirkpatrick

EstroGene2.0: A multi-omic database of response to estrogens, ER-modulators, and resistance to endocrine therapies in breast cancer

EstroGene2.0 is a multi-omic database that compiles data on estrogen receptor responses and resistance in breast cancer, revealing diverse transcriptomic changes and identifying key targets.

m6A reader Pho92 is recruited co-transcriptionally and couples translation efficacy to mRNA decay to promote meiotic fitness in yeast

Identification of RNA base pairs and complete assignment of nucleobase resonances by proton-detected solid-state NMR spectroscopy at 100 kHz MAS

This paper uses proton-detected solid-state NMR to determine RNA base pairs and nucleobase resonances in RNA and RNA-protein complexes without requiring crystallization.

Late life metformin treatment limits cell survival and shortens lifespan by triggering an aging-associated failure of energy metabolism.

This study shows that late-life metformin treatment reduces cell survival and lifespan by impairing energy metabolism, contrasting its beneficial effects in early life.

Noninvasive lung cancer detection via pulmonary protease profiling

This study uses activity-based nanosensors to detect early-stage lung cancer in mice with high sensitivity and specificity through urinary readouts of protease activity.