A. Ori

Proteome dynamics reveal Leiomodin 1 as a key regulator of myogenic differentiation

The paper identifies LMOD1 as a key regulator of myogenic differentiation through proteome dynamics and functional studies.

Automated workflow for BioID improves reproducibility and identification of protein-protein interactions

The paper introduces an automated workflow for BioID to improve reproducibility and identification of protein-protein interactions by increasing throughput and reducing sample input requirements.

ProteasomeID: quantitative mapping of proteasome interactomes and substrates for in vitro and in vivo studies

This study develops a method to quantify proteasome interactomes and substrates in vivo using biotin ligases and a new mouse model, identifying novel interactors and substrates.

Computational and biochemical analysis of type IV Pilus dynamics and stability

The paper uses molecular dynamics simulations and biochemical experiments to study T4P stability, identifying a calcium-binding site important for function and suggesting it as a drug target.

Mapping sites of carboxymethyllysine modification on proteins reveals its consequences for proteostasis and cell proliferation

This study maps carboxymethyllysine (CML) modification sites on proteins in mouse and human cells, showing its impact on proteostasis and cell proliferation.

Late life metformin treatment limits cell survival and shortens lifespan by triggering an aging-associated failure of energy metabolism.

This study shows that late-life metformin treatment reduces cell survival and lifespan by impairing energy metabolism, contrasting its beneficial effects in early life.

Transcriptome analysis in whole blood reveals increased microbial diversity in schizophrenia

The paper analyzes the transcriptome of whole blood to find increased microbial diversity in schizophrenia patients compared to controls and other neurological disorders.