A. Mugler

Optimal antimicrobial response to a changing microbial background at a mucus interface

The paper develops a minimal model to explain how hosts optimize antimicrobial defense at the intestinal mucus interface by integrating signals from bulk microbiota and segmented filamentous bacteria.

Signaling in microbial communities with open boundaries

This study uses mathematical modeling to show how boundary flows and population geometry affect cell-cell signaling in microbial communities with open boundaries, revealing new insights into signaling mechanisms and making experimentally verifiable predictions.

The fidelity of genetic information transfer with aging skeletal muscle segregates according to biological processes

The paper quantifies age-related decline in transcription factor-target gene communication efficiency using single-cell RNA-seq data from skeletal muscle.

A computational model of fractal interface formation in bacterial biofilms

The paper presents a computational model of bacterial biofilm interface formation, showing fractal patterns emerge from cell-level interactions and mechanical forces.

Cells function as a ternary logic gate to decide migration direction under integrated chemical and fluidic cues

The paper investigates how cells process chemical and fluidic cues to decide migration direction, finding that their signal processing functions as a ternary logic gate.

Intermediate adhesion maximizes fluidity and migration velocity of multicellular clusters

This study shows that intermediate cell-cell adhesion optimizes migration speed of multicellular clusters by balancing cohesion and fluidity.

Signal processing capacity of the cellular sensory machinery regulates the accuracy of chemotaxis under complex cues

The paper shows that the signal processing capacity of the cellular sensory machinery limits chemotactic accuracy under complex cues, using TGF-β and EGF as an example.

Diffusion vs. direct transport in the precision of morphogen readout

The paper compares diffusion and direct transport mechanisms for morphogen profile precision, finding diffusion is more precise for longer profiles due to higher refresh rates.

Modeling of cytometry data in logarithmic space: when is a bimodal distribution not bimodal?

The paper shows that bimodal distributions in logarithmic cytometry data may reflect unimodal distributions in linear scale and introduces a test to detect this mismatch.