B. Han

High Throughput Screening with a Primary Human Mucociliary Airway Model Identifies a Small Molecule with Anti-SARS-CoV-2 Activity

This study uses a primary human stem cell-based airway model to screen 2100 compounds and identifies a small molecule effective against SARS-CoV-2 and its Omicron variant.

Differences in milk microbiota between healthy cows and cows with recurring Klebsiella mastitis

The paper compares milk microbiota between healthy cows and those with recurring Klebsiella mastitis, finding differences in bacterial genera associated with infection.

Environmental and ecological signals predict periods of nutritional stress for Eastern Australian flying fox populations.

The paper uses explainable AI to predict food shortages in Eastern Australian flying foxes, identifying environmental and bat-level features that predict nutritional stress with high accuracy.

Perivascular Excitation Tunnelling: a Novel and Preventable Cause of Cardiac Reperfusion Arrhythmias

This study identifies perivascular excitation tunnelling (PVET) as a novel mechanism causing reperfusion arrhythmias and shows that two-step reperfusion can prevent it in rabbit and pig hearts.

High clonal diversity and spatial genetic admixture in early prostate cancer and surrounding normal tissue

Unbiased phosphoproteomics analysis unveils modulation of insulin signaling by extramitotic CDK1 kinase activity in human myotubes

The paper uses phosphoproteomics to show that CDK1 activity modulates insulin signaling and glucose uptake in human myotubes, with group-specific phosphorylation changes observed.

Microsporidia dressing up: the spore polaroplast transport through the polar tube and transformation into the sporoplasm membrane

This study investigates the formation of the sporoplasm membrane during microsporidia spore germination, revealing that the polaroplast transforms into the sporoplasm membrane via the polar tube.

The maize PLASTID TERMINAL OXIDASE (PTOX) gene controls the carotenoid content of kernels.

This study identifies ZmPTOX1 as a key gene for carotenoid biosynthesis in maize kernels, showing that its disruption reduces carotenoid content while overexpression increases it, particularly beta-carotene.

Evolutionarily diverse caveolins share a common structural framework built around amphipathic discs

The paper predicts structures for 73 caveolins across animal diversity and identifies conserved structural elements and amphipathic disc assembly, revealing an ancient structural framework predating Metazoa.

SARS-CoV-2 spike-induced syncytia are senescent and contribute to exacerbated heart failure

This study links SARS-CoV-2 spike-induced syncytia to cellular senescence and exacerbated heart failure, showing that senolytic drugs and WNK1 inhibitors can mitigate cardiac damage.

Comparative genomic analyses of Lactococcus garvieae isolated from bovine mastitis in China

This study characterizes Lactococcus garvieae isolates from bovine mastitis in China, identifying genetic diversity, antimicrobial resistance, virulence factors, and potential host adaptation.

Template-free prediction of a new monotopic membrane protein fold and oligomeric assembly by Alphafold2

This study uses AlphaFold2 to predict the structure of caveolin-1, revealing its new fold and oligomeric assembly, but notes limitations in predicting higher-order complexes.

Structural characterization of a breast cancer-associated mutation in caveolin-1

This study examines how a breast cancer-associated mutation in CAV1, P132L, affects its structure and oligomerization, revealing its impact on caveolae formation.

Social Regulation of Egg Size Plasticity in the Honey Bee is Mediated by Cytoskeleton Organizer Rho1

This study identifies Rho1 as a key regulator of egg size plasticity in honey bees, showing queens adjust egg size based on colony size through molecular changes involving energy metabolism and cytoskeleton functions.

Cells function as a ternary logic gate to decide migration direction under integrated chemical and fluidic cues

The paper investigates how cells process chemical and fluidic cues to decide migration direction, finding that their signal processing functions as a ternary logic gate.

Tree species and genetic diversity increase productivity via functional diversity and trophic feedbacks

This study shows that both tree species and genetic diversity increase productivity through functional diversity and trophic feedbacks, with genetic diversity effects varying between monocultures and mixtures.

Boosting transformation in wheat by BBM-WUS

This paper introduces a heat-shock protocol for wheat transformation that significantly improves efficiency using BBM-WUS, reducing the time to obtain transgenic plants to 60 days.

Introducing an argonaute-facilitated PCR platform

This paper introduces an argonaute-facilitated PCR platform that improves PCR sensitivity by using MejAgo to enhance guide DNA/template pairing, eliminating the need for an annealing step.

Molecular architecture of the human caveolin-1 complex

The paper uses cryo-electron microscopy to reveal the structure of the human caveolin-1 complex, showing it forms a disc with a flat membrane-binding surface.

Activation of transient receptor potential vanilloid 4 is involved in pressure overload-induced cardiac hypertrophy

This study shows TRPV4 activation contributes to pressure overload-induced cardiac hypertrophy through Ca2+/CaMKII-mediated NFκB-NLRP3 activation, suggesting TRPV4 as a therapeutic target.

OsMADS58 stabilizes gene regulatory circuits during rice stamen development

This study identifies OsMADS58's role in stabilizing gene regulatory circuits during rice stamen development using CRISPR knockout and transcriptomic analysis.

Potential transmission chains of variant B.1.1.7 and co-mutations of SARS-CoV-2

The paper analyzes SARS-CoV-2 mutations and co-mutations, suggesting Canidae as a possible host for the B.1.1.7 variant and showing that co-mutations significantly reduce viral replication.

The first report and biological characteristics of Helcococcus ovis isolated from clinical bovine mastitis in a Chinese dairy herd

This study isolates and characterizes Helcococcus ovis from clinical bovine mastitis in China, showing its antimicrobial sensitivity and pathogenic potential in a murine model.

Neuromodulation of Behavioral Specialization: Tachykinin Signaling Inhibits Task-Specific Behavioral Responsiveness in Honeybee Workers

This study identifies tachykinin peptides as regulators of task-specific behavioral responsiveness in honeybee workers by manipulating their expression and observing behavioral outcomes.

Signal processing capacity of the cellular sensory machinery regulates the accuracy of chemotaxis under complex cues

The paper shows that the signal processing capacity of the cellular sensory machinery limits chemotactic accuracy under complex cues, using TGF-β and EGF as an example.

Regulation of extracellular matrix assembly and structure by hybrid M1/M2 macrophages

This study shows hybrid M1/M2 macrophages regulate ECM assembly, with M2 polarization promoting less fibrotic ECM structure.

Multi-site co-mutations and 5'UTR CpG immunity escape drive the evolution of SARS-CoV-2

The paper identifies four dominant mutations, three significant multi-site co-mutations, and a 5'UTR CpG escape mutation that drive the rapid evolution of SARS-CoV-2.

Expression of Ace2, Tmprss2, and Furin in mouse ear tissue

This study examines the expression of Ace2, Tmprss2, and Furin in mouse ear tissues, finding co-expression in the middle ear that suggests susceptibility to SARS-CoV-2.

Structure and assembly of CAV1 8S complexes revealed by single particle electron microscopy

This study uses single particle electron microscopy to reveal the structure of human CAV1 8S complexes, showing they are toroidal with distinct rings and stalks, and provides insights into their assembly.

Fructose Metabolism Contributes to the Warburg effect

This study shows cancer cells use fructose metabolism to drive the Warburg effect by converting glucose to fructose via polyol pathways and exporting fructose to the tumor microenvironment.