Methotrexate inhibition of muropeptide transporter SLC46A2 controls psoriatic skin inflammation
R. Bharadwaj, C. F. Lusi, S. Mashayekh, A. Nagar, R. K. S. Malireddi, G. I. Kane, K. Wodzanowski, A. Brown, K. Okuda, A. Monahan, D. Paik, A. Nandy, M. Anonick, W. E. Goldman, T.-D. Kanneganti, , N. Silverman
The paper shows that SLC46A2 transports DAP-muropeptides to activate NOD1 in keratinocytes, and methotrexate inhibits this transport, reducing psoriatic inflammation.
bioRxiv · Sep 29, 2022 · PreprintImmunology