Synthesis and validation of click-modified of NOD1/2 agonists
R. Bharadwaj, M. V. Anonick, S. Mashayekh…·C. L. Grimes
This study synthesizes and validates click-modified muropeptides as tools to study NOD1/2 innate immune sensing mechanisms.
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4 papers
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R. Bharadwaj, M. V. Anonick, S. Mashayekh…·C. L. Grimes
This study synthesizes and validates click-modified muropeptides as tools to study NOD1/2 innate immune sensing mechanisms.
R. Bharadwaj, C. F. Lusi, S. Mashayekh…·N. Silverman
The paper shows that SLC46A2 transports DAP-muropeptides to activate NOD1 in keratinocytes, and methotrexate inhibits this transport, reducing psoriatic inflammation.
P. Sreejith, S. Lolo, K. R. Patten…·R. Bharadwaj
This study identifies Nazo, the Drosophila homolog of c19orf12, as essential for triglyceride homeostasis, linking lipid metabolism to neurodegeneration.
E. Jalbert, C. Liu, V. Mave…·A. Weinberg
This study compares immune responses between individuals with sterilizing protection against TB and those with latent infection to identify potential vaccine targets.