C. L. Grimes

Synthesis and validation of click-modified of NOD1/2 agonists

This study synthesizes and validates click-modified muropeptides as tools to study NOD1/2 innate immune sensing mechanisms.

Methotrexate inhibition of muropeptide transporter SLC46A2 controls psoriatic skin inflammation

The paper shows that SLC46A2 transports DAP-muropeptides to activate NOD1 in keratinocytes, and methotrexate inhibits this transport, reducing psoriatic inflammation.

Multiscale Invasion Assay for Probing Macrophage Response to Bacteria

This paper introduces a 3D culture system to study macrophage response to bacteria, showing cytokine release and in situ peptidoglycan labeling.

FtsW exhibits distinct processive motions driven by either septal cell wall synthesis or FtsZ treadmilling in E. coli

This study identifies two distinct processive motions of FtsW in E. coli, driven by FtsZ treadmilling or septal peptidoglycan synthesis, revealing a two-track model for sPG synthesis regulation.

Bacterial Peptidoglycan Fragments Deferentially Regulate Innate Immune Signaling

This study synthesizes PG-based disaccharide ligands and screens them against BMDMs to reveal distinct gene induction patterns compared to monosaccharides, showing complex innate immune signaling.

Distinct cytoskeletal proteins define zones of enhanced cell wall synthesis in Helicobacter pylori

The paper identifies cytoskeletal proteins that regulate cell wall synthesis in Helicobacter pylori, linking their distribution to specific Gaussian curvatures that maintain helical shape.