Author

A. Orian

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Organism:Drosophila· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1

Frequent Co-Authors

C. Prieto-Garcia· 2 shared M. E. Diefenbacher· 2 shared M. Eilers· 2 shared M. Reissland· 2 shared M. Rosenfeldt· 2 shared O. Hartmann· 2 shared A. C. Jacomin· 1 shared A. Cammarata-Mouchtouris· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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2 shared papersCancer Biology

C. Prieto-Garcia

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Stabilisation of β-Catenin-WNT signalling by USP10 in APC-truncated colorectal cancer drives cancer stemness and enables super-competitor signalling

M. Reissland, O. Hartmann, S. Tauch, C. Prieto-Garcia, C. Schulte, D. Solvie, S. Loebbert, A. C. Jacomin, M. Pesic, J. M. Bugter, C. Schuelein-Voelk, C. Fuss, N. Pahor, C. Ade, V. Buck, , M. E. Diefenbacher

This study identifies USP10 as a deubiquitylase that stabilizes β-Catenin in APC-truncated colorectal cancer, enhancing WNT signaling and cancer stemness.

bioRxiv · Feb 10, 2023 · PreprintCancer Biology

The USP28-{triangleup}Np63 axis is a vulnerability of squamous tumours

C. Prieto-Garcia, O. Hartmann, M. Reissland, F. Braun, T. Fischer, S. Walz, A. Fischer, M. Calzado, A. Orian, M. Rosenfeldt, M. Eilers, M. E. Diefenbacher

This study identifies USP28 as a stabilizer of {Delta}Np63 in squamous cell carcinomas, showing that inhibiting USP28 reduces tumor growth and survival.

bioRxiv · Jun 27, 2019Cancer Biology

Hyd ubiquitinates the NF-κB co-factor Akirin to activate an effective immune response in Drosophila

A. Cammarata-Mouchtouris, X.-H. Nguyen, F. Bonnay, A. Goto, A. Orian, M.-O. Fauvarque, M. Boutros, J.-M. Reichhart, N. Matt

This study identifies Hyd as an E3-ubiquitin ligase that ubiquitinates Akirin to enhance Relish binding and activate immune effector genes in Drosophila.

bioRxiv · Jul 20, 2018Immunology