C. Schulte

Genome-wide association study of copy number variations in Parkinson's disease

This study conducts a genome-wide association study of copy number variations in Parkinson's disease, identifying a significant PRKN deletion but limited replication in an independent dataset.

Induction of Hepatitis B Core Protein Aggregation Targeting an Unconventional Binding Site

This study identifies two binding sites on the HBV capsid and demonstrates peptides that induce HBc aggregation in vitro and in cells.

Stabilisation of β-Catenin-WNT signalling by USP10 in APC-truncated colorectal cancer drives cancer stemness and enables super-competitor signalling

This study identifies USP10 as a deubiquitylase that stabilizes β-Catenin in APC-truncated colorectal cancer, enhancing WNT signaling and cancer stemness.

Native extracellular matrix probes to target patient- and tissue- specific cell-microenvironment interactions by force spectroscopy

The paper develops native ECM AFM probes to study cell-microenvironment interactions, showing they preserve ECM complexity and reveal region-specific adhesion patterns in bladder cancer cells.

A bead-based GPCR phosphorylation immunoassay for high-throughput ligand profiling and GRK inhibitor screening

This paper develops a bead-based immunoassay to quantify GPCR phosphorylation for ligand profiling and GRK inhibitor screening, demonstrating its utility with selective inhibitors.

Force sensing on cells and tissues by atomic force microscopy

This paper applies atomic force microscopy to quantify biomechanical properties of biological systems, showing correlations between mechanical changes and physiological or pathological conditions.

Link between aging and atheroprotection in Mif-deficient atherosclerotic mice

This study investigates how Mif deficiency affects atheroprotection in aging Apoe-/- mice, finding that atheroprotective effects diminish with age.

The glycocalyx affects the mechanotransductive perception of the topographical microenvironment

This study shows that glycocalyx configuration influences mechanotransductive responses of PC12 cells to nanotopographical cues through changes in actin dynamics and force loading.

Stiffening of prostate cancer cells driven by actin filaments - microtubules crosstalk confers resistance to microtubule-targeting drugs

This study shows that prostate cancer cells stiffen in response to microtubule-targeting drugs due to actin-microtubule crosstalk, contributing to drug resistance.

Adhesion force spectroscopy with nanostructured colloidal probes reveals nanotopography-dependent early mechanotransductive interactions at the cell membrane level

This study uses adhesion force spectroscopy with nanostructured colloidal probes to show that nanotopography influences early mechanotransductive interactions by modulating force loading and integrin clustering in cell adhesion.

Neuronal Cells Confinement by Micropatterned Cluster-Assembled Dots with Mechanotransductive Nanotopography

This paper develops micropatterned substrates with nanotopographical features to confine and guide neuronal cell growth and differentiation through mechanotransductive signaling.