T. Fischer

Immune Correlates of Hyperglycemia and Vaccination in a Non-human Primate Model of Long-COVID

This study establishes a non-human primate model of metabolic PASC, identifies immune correlates of hyperglycemia, and shows vaccine-induced glycemic improvement.

Unveiling the signaling network of FLT3-ITD AML improves drug sensitivity prediction

This study develops a systems-based strategy to predict drug sensitivity in FLT3-ITD AML by integrating genomic, transcriptomic data with a prior-knowledge signaling network.

A key role of the WEE1-CDK1 axis in mediating TKI-therapy resistance in FLT3-ITD positive acute myeloid leukemia patients

The paper identifies the WEE1-CDK1 axis as a key driver of TKI resistance in FLT3-ITD positive AML and suggests combination therapy as a potential treatment.

PTEN mutant NSCLC require ATM to suppress pro-apoptotic signalling and evade radiotherapy

This study shows PTEN-deficient NSCLC cells rely on ATM to repair radiation damage and resist therapy, and ATM inhibition synergizes with radiation in these models.

Inhibition of USP28 overcomes Cisplatin-Resistance of Squamous Tumors by Suppression of the Fanconi Anemia Pathway.

This study identifies USP28 inhibition as a strategy to overcome cisplatin resistance in squamous cell carcinomas by suppressing the Fanconi Anemia DNA repair pathway.

Cellular events of acute, resolving or progressive COVID-19 in SARS-CoV-2 infected non-human primates

This study examines immune events in non-human primates infected with SARS-CoV-2, identifying cellular correlates of disease severity and potential therapeutic targets.

Dynamic sound field audiometry: static and dynamic spatial hearing tests in the full horizontal plane

This study evaluates dynamic spatial hearing tests using a new setup, finding better performance in frontal azimuth and improved tracking with head movement.

PGRMC1 phosphorylation and cell plasticity 2: genomic integrity and CpG methylation

This study shows that PGRMC1 phosphorylation mutants alter genomic stability, CpG methylation, and cell metabolism, suggesting a role in cellular plasticity and tissue differentiation.

The USP28-{triangleup}Np63 axis is a vulnerability of squamous tumours

This study identifies USP28 as a stabilizer of {Delta}Np63 in squamous cell carcinomas, showing that inhibiting USP28 reduces tumor growth and survival.