Aberrant MNX1 Expression Associated with t(7;12)(q36;p13) Pediatric Acute Myeloid 1 Leukemia Induces the Disease Through Altering Histone Methylation
A. Waraky, A. Ostlund, T. Nilsson, D. Weichenhan, P. Lutsik, M. Baehr, J. Hey, J. Adamsson, M. H. A. Morsy, S. Li, L. Fogelstrand, C. Plass, L. Palmqvist
This study identifies MNX1 as a driver of t(7;12)(q36;p13) pediatric AML by altering histone methylation and shows that targeting MNX1 can prevent leukemia development.
bioRxiv · Jun 10, 2022Cancer Biology