E. Akdogan

Cell migration CRISPRi screens in human neutrophils reveal regulators of context-dependent migration and differentiation state

The paper uses CRISPRi screens in human neutrophils to identify genes regulating context-dependent migration and differentiation.

Phosphate Starvation Signaling Increases Mitochondrial Membrane Potential through Respiration-independent Mechanisms

The paper shows phosphate starvation increases mitochondrial membrane potential through respiration-independent mechanisms in yeast and mammalian cells.

Signaling dynamics distinguish high and low priority neutrophil attractant receptors

The paper shows that high and low priority neutrophil attractants elicit distinct signaling dynamics, with high priority signals being sustained and low priority signals being transient.

Optogenetic control of receptors reveals distinct roles for actin- and Cdc42-dependent negative signals in chemotactic signal processing

The paper uses optogenetic tools to show that F-actin and Cdc42 provide distinct negative signals that limit Cdc42 activation during chemotaxis.

A bacteria-derived tail anchor localizes to peroxisomes in yeast and mammalian cells

The paper shows that a bacteria-derived tail anchor from E. coli localizes to peroxisomes in yeast and mammalian cells, suggesting its utility in studying peroxisomal targeting mechanisms.

Deep mutational scanning reveals characteristics important for targeting of the tail-anchored protein Fis1

The paper uses deep mutational scanning to analyze the tail-anchored domain of Fis1p, revealing that positively charged residues are critical for mitochondrial targeting and that TA length does not dictate organelle specificity.