J. A. Theriot

The paper analyzes immune cell interactions using traction force microscopy to identify biomechanical features associated with cytotoxic T cell activity.

This study shows that 2D confinement alters keratocyte shape and reduces both cell speed and volume by 20%, suggesting a link between cell volume and migration speed.

This study uses CRISPRi screening and deep learning to identify genes affecting cell morphology and construct a quantitative morphological variation space in human cells.

The paper uses CRISPRi screens in human neutrophils to identify genes regulating context-dependent migration and differentiation.

This study identifies TREM2, CD14, and integrin αMβ2 as essential cell surface receptors for PS-mediated phagocytosis, revealing distinct mechanisms for PS and antibody-coated target uptake.

This study shows that zebrafish epidermis forms fissures post-injury due to hydraulic fracturing driven by osmotic pressure, with myosin II involvement and fluid clearance via macropinocytosis.

The paper measures cytoplasmic diffusion heterogeneity in fission yeast using nanorheology and simulations, finding large variations in viscosity that are not explained by experimental variability.

This study identifies E-cadherin ubiquitination and caveolin-mediated trafficking as mechanisms enabling Listeria monocytogenes to spread between epithelial cells.

This study shows neutrophils resolve directional dilemmas by committing to one leading edge late in the decision process, influenced by mechanical stretching and receptor inputs.

The paper analyzes gene expression changes in hiPSC-derived cardiomyocytes using single-cell RNA-seq, identifying key genes that mark differentiation stages and sources of variation across protocols and cell lines.

The paper uses microscopy and force measurement techniques to show how localized actin and myosin forces drive target constriction during phagocytosis, revealing a distinct mechanism from 2D cell motility.

The paper shows that entropy drives disordered proteins through Gram-positive bacterial cell walls, using a physical model and experimental validation.

This study shows lamellipodial stability in migrating cells arises from actin network geometry without additional feedback, explaining the conservation of the Arp2/3 branching angle.

This study shows zebrafish skin cells detect injury via both osmolarity and electrical cues, with sodium chloride-specific sensing independent of cell swelling.

This paper compares PCA and VAE-GAN for analyzing cell shape in neutrophils, finding that VAE-GAN more efficiently captures shape variation while maintaining interpretability.

The paper integrates gene expression and sarcomere organization in hiPSC-derived cardiomyocytes to predict subcellular states and reveal correlations between transcript abundance and structural patterns.

The paper shows that innate immune signaling triggers mechanical competition, leading to the collective extrusion of infected epithelial cells by uninfected bystanders.

This paper develops a superresolution traction force microscopy method to measure subcellular forces in immune cell-target interactions without using embedded tracers.

The paper investigates how mechanical asymmetries at the rear of fish keratocytes drive cell turning, showing that actin flow and myosin II contractility, rather than leading edge protrusion, are key to steering migration.

This study shows that L. monocytogenes spreads heterogeneously in epithelial cells, with rare pioneer bacteria driving infection spread and persistence.

This study shows that ECM stiffness affects Listeria monocytogenes infection of endothelial cells via cell surface vimentin and FAK activity.

This study identifies InlP as a Listeria monocytogenes protein that binds afadin to facilitate transcytosis across epithelial monolayers during placental infection.