Non-canonical Telomerase Reverse Transcriptase Controls Osteogenic Reprogramming of Aortic Valve Cells Through STAT5
R. A. Cuevas, L. Hortells, C. Chu, R. Wong, A. Crane, C. Boufford, C. Regan, W. Moorhead, M. Bashline, A. Parwal, A. Parise, P. Behzadi, A. Gurkar, D. Bruemmer, J. Sembrat, , C. St. Hilaire
This study identifies TERT's non-canonical role in osteogenic reprogramming of aortic valve cells through STAT5, offering a potential therapeutic target for calcific aortic valve disease.
bioRxiv · Aug 23, 2022Pathology