Age-related structural and functional changes of the intracardiac nervous system
L. Hortells, C. M. Zgierski-Johnston, P. Kohl, F. Schneider-Warme, U. Ravens, S. Preissl, B. A. Cameron, M. Koch, T. A. Brennan, J. Madl, P. Iaconianni, M. C. Fernandez, D. Stefanovska, G. Tumlinson, E. Sassu
This study examines age-related changes in cardiac Schwann cells, parasympathetic nerve fibers, and M2R expression in mice, finding reduced SC density, fewer parasympathetic fibers, and lower M2R expression in aged hearts, which correlates with increased arrhythmia risk.
bioRxiv · Nov 24, 2023Physiology