Author

A. Lau

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 3 Ecology· 2 Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:development & morphogenesis· 2 Research Focus:ecology & biodiversity· 2 Research Focus:host-pathogen & immune response· 2 Assay:cryo-EM· 1 Approach:deep learning· 1

Frequent Co-Authors

C. O'Rourke· 2 shared G. Uzer· 2 shared S. Birks· 2 shared S. Howard· 2 shared W. R. Thompson· 2 shared A. C. N. Sim· 1 shared A. Chandramohan· 1 shared A. Loboda· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersBioengineering

C. O'Rourke

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Author profile →

7 papers

Recent·Most cited

Environmental factors and host sex influence the skin microbiome structure of Hong Kong newt (Paramesotriton hongkongensis) in a coldspot of chytridiomycosis in subtropical East Asia

B. Wan, G. Chen, E. S. K. Poon, H. S. Fung, A. Lau, S. Y. W. Sin

The paper investigates the skin microbiome of Hong Kong newts, finding that environmental factors and host sex influence its composition, with core microbes potentially aiding resistance to chytridiomycosis.

bioRxiv · Feb 19, 2024 · PreprintEcology

Prrx1-driven LINC complex disruption in vivo reduces osteoid deposition but not bone quality after voluntary wheel running

S. Birks, S. Howard, C. S. Wright, C. O'Rourke, A. Lau, W. R. Thompson, G. Uzer

This study shows that disrupting the LINC complex in bone progenitor cells reduces exercise-induced osteoid deposition but not bone quality in mice.

bioRxiv · Sep 22, 2023Bioengineering

Osterix-driven LINC complex disruption in vivo diminishes bone microarchitecture in 8-week male mice but not after 6-week voluntary wheel running

S. Birks, S. Howard, C. O'Rourke, W. R. Thompson, A. Lau, G. Uzer

This study examines the effect of Osterix-driven LINC complex disruption on bone microarchitecture in mice, finding reduced bone quality at 8 weeks but no significant change after 6 weeks of voluntary running.

bioRxiv · Aug 24, 2023 · PreprintBioengineering

STUB1 is an intracellular checkpoint for interferon gamma sensing

S. Ng, S. Lim, A. C. N. Sim, R. Mangadu, A. Lau, C. Zhang, S. Bollinger Martinez, A. Chandramohan, U.-M. Lim, S. S. W. Ho, S. C. Chang, P. Gopal, L. Z. Hong, A. Schwaid, A. Z. Fernandis, , A. W. Partridge

This study identifies STUB1 as a barrier to interferon gamma sensing, showing it dampens IFNγ response through reduced IFNGR1 surface abundance, but in vivo STUB1 inactivation did not improve ICB outcomes in mouse models.

bioRxiv · Dec 14, 2020Cancer Biology

First record of the Australian redclaw crayfish Cherax quadricarinatus (von Martens 1868) in Hong Kong, China

A. Lau, S.-m. Yau

The paper reports the first record of the invasive Australian redclaw crayfish in Hong Kong, China, and calls for further ecological impact studies and management strategies.

bioRxiv · Nov 17, 2020Ecology

Multi-ATOM: Ultrahigh-throughput single-cell quantitative phase imaging with subcellular resolution

K. Lee, A. Lau, A. Tang, M. Wnag, A. Mok, B. Chung, W. Yan, H. C. Shum, K. Cheah, G. Chan, H. So, K. Wong, K. Tsia

The paper introduces multi-ATOM, a high-throughput QPI method that enables subcellular resolution and accurate cell-type classification without compromising speed or quality.

bioRxiv · Jan 3, 2019Bioengineering

Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosome

S. V. Faull, A. Lau, C. Martens, Z. Ahdash, H. Yebenes, C. Schmidt, F. Beuron, N. B. Cronin, E. P. Morris, A. Politis

The paper determines the structure and dynamics of CSN-CRL2 complexes using cryo-EM and mass spectrometry, revealing a stepwise activation mechanism.

bioRxiv · Nov 29, 2018Biochemistry