Mining for disease-associated microbial metabolites in an age-dependent model of multiple sclerosis
A. Pu, N. Fettig, A. Polyzois, G. Chao, I. Naouar, L. Hohman, M. A. Fontaine, M. Zuo, K. Champagne-Jorgensen, J. Copeland, D. Chan, K. M. Davis, R. Yu, S. Popple, N. A. Carranza Garcia, , L. C. Osborne
The paper identifies a microbial metabolite, indole 3-propionic acid, that can reverse non-remitting EAE in aged mice, suggesting therapeutic potential for progressive MS.
bioRxiv · May 27, 2024 · PreprintImmunology