R. Yu

Mining for disease-associated microbial metabolites in an age-dependent model of multiple sclerosis

The paper identifies a microbial metabolite, indole 3-propionic acid, that can reverse non-remitting EAE in aged mice, suggesting therapeutic potential for progressive MS.

Insulin Resistance Increases TNBC Aggressiveness and Brain Metastasis via Adipocyte-derived Exosomes

This study shows insulin-resistant adipocyte exosomes promote TNBC aggressiveness and brain metastasis via miRNA pathways.

Multi-Omics Analysis Reveals the Attenuation of the Interferon Pathway as a Driver of Chemo-Refractory Ovarian Cancer

The paper identifies reduced IFN-I pathway activity as a driver of chemo-refractory ovarian cancer using multi-omics analysis in a clinical trial cohort.

ROCK1 activates mitochondrial fission leading to oxidative stress and muscle atrophy

This study identifies ROCK1 activation as a driver of mitochondrial fission and oxidative stress in CKD-induced muscle wasting, showing pharmacological inhibition of ROCK1 can alleviate these effects.

Dual Ethanolamine Head Groups in Ionizable Lipids Facilitate Phospholipid-free Stable Nanoparticle Formulation for Augmented and Safer mRNA Delivery

This paper introduces ionizable lipids with dual ethanolamine head groups for phospholipid-free mRNA delivery, showing improved stability, efficiency, and reduced toxicity.

Single cell analysis uncovers striking cellular heterogeneity of lung infiltrating Tregs during eosinophilic vs. neutrophilic allergic airway inflammation

The paper uses single-cell RNA sequencing to analyze lung-infiltrating Tregs in eosinophilic and neutrophilic allergic airway inflammation models, revealing significant heterogeneity and tissue-residency differences.

Intronic miR342 is a master regulator of cellular glycolysis in Foxp3+ regulatory CD4 T cells

This study identifies miR-342 as a master regulator of glycolysis in Foxp3+ regulatory T cells, essential for controlling inflammation in the central nervous system.

Nuclear speckles regulate HIF-2α programs and correlate with patient survival in kidney cancer

This study shows nuclear speckles vary in cancer, correlate with survival in kidney cancer, and are regulated by HIF-2 through speckle targeting motifs.

Amyloplast sedimentation repolarizes LAZYs to achieve gravity sensing in plants

This study identifies a molecular mechanism by which amyloplast sedimentation triggers LAZY protein relocalization to mediate gravity sensing in Arabidopsis.

Lymphocyte activation gene 3 (Lag3) supports Foxp3+ Treg cell function by restraining c-Myc-dependent aerobic glycolysis

This study shows Lag3 supports Foxp3+ Treg cell function by restraining c-Myc-dependent aerobic glycolysis, which is critical for suppressing autoimmune inflammation.

Modular Pooled Discovery of Synthetic Knockin Sequences to Program Durable Cell Therapies

The paper develops ModPoKI, a platform for modular construction of DNA knockin libraries to identify gene constructs that enhance T cell function and persistence.

Novel plasma exosome biomarkers for prostate cancer progression in co-morbid metabolic disease

This study identifies plasma exosomal miRNAs associated with T2D that induce EMT and immune checkpoint expression in prostate cancer cells.

Multiplexed imaging mass cytometry reveals distincttumor-immune microenvironments linked to immunotherapyresponses in melanoma

This study uses imaging mass cytometry to analyze tumor-immune microenvironments in melanoma patients, identifying distinct microenvironment archetypes linked to responses to anti-PD-1 therapy.

Yn-situ: a robust single RNA molecule in situ detection method

The paper introduces Yn situ, a single RNA molecule in situ detection method, showing it is sensitive and quantitative for gene expression in mouse olfactory epithelia.

Anaerobic biodegradation of chloroform and dichloromethane with a Dehalobacter enrichment culture

This study investigates the anaerobic biodegradation of chloroform and dichloromethane using a microbial enrichment culture, finding that oxidation of dichloromethane supports further dechlorination of chloroform.

Amino acid and nucleotide metabolism shape the selection of trophic levels in animals

The paper examines how amino acid and nucleotide metabolism influence trophic levels in animals by analyzing genome-scale metabolic models.

Daily running enhances molecular and physiological circadian rhythms in skeletal muscle

This study shows that daily running in mice changes their muscle circadian rhythms and improves exercise performance depending on the time of day.

Plasma non-esterified fatty acids contribute to increased coagulability in type-2 diabetes through altered plasma zinc speciation

The paper shows that elevated NEFA levels in T2DM alter plasma zinc speciation, increasing coagulability and thrombotic risk.

Snipe: Highly sensitive pathogen detection from metagenomic sequencing data

The paper introduces a method to improve pathogen detection in metagenomic data by correcting abundance estimates using species-specific genomic regions, enhancing sensitivity and specificity for low-abundance pathogens.

Ratio of the interferon-γ signature to the immunosuppression signature predicts anti-PD-1 therapy response in melanoma

The paper identifies an immunosuppression signature (IMS) and shows that its ratio to an IFN-γ signature better predicts anti-PD-1 therapy response in melanoma than existing biomarkers.

The effects of biodegradable mulch film on the growth, yield, and water use efficiency of cotton and maize in an arid region

This study compares biodegradable mulch film with polyethylene plastic film in cotton and maize, finding higher yield and water use efficiency with biodegradable film without residual pollution.

Rapid discovery of synthetic DNA sequences to rewrite endogenous T cell circuits

This paper develops a platform to discover synthetic DNA sequences that enhance T cell functions by integrating them into endogenous genomic sites.