A. R. Williams

Adhesion of Crithidia fasciculata promotes a rapid change in developmental fate driven by cAMP signaling

This study investigates how adhesion triggers differentiation in Crithidia fasciculata, showing cAMP signaling is critical for attachment and involves reorganization of signaling components along the flagellum.

Dietary non-starch polysaccharides impair immunity to enteric nematode infection

This study shows that high levels of non-starch polysaccharides in diet impair type-2 immunity and increase susceptibility to enteric helminth infections in mice.

Cdc42 GTPase activating proteins Rga4 and Rga6 coordinate septum synthesis and membrane trafficking at the division plane during cytokinesis

This study shows that Rga4 and Rga6 reduce Cdc42 activity during late cytokinesis to coordinate septum formation with membrane trafficking in fission yeast.

Garlic-derived organosulfur compounds regulate metabolic and immune pathways in macrophages and attenuate intestinal inflammation in mice

This study shows garlic-derived organosulfur compounds reduce inflammation in macrophages and intestinal epithelial cells, and alter gene expression during intestinal infection in mice.

Dietary Proanthocyanidins Exert Localized Immunomodulatory Effects in Porcine Pulmonary and Gastrointestinal Tissues during Ascaris suum-induced Type 2 inflammation

This study shows that dietary proanthocyanidins enhance intestinal immune and antioxidant responses but have limited effects on pulmonary type-2 inflammation during Ascaris suum infection in pigs.

Parasite-probiotic interactions in the gut: Bacillus sp. and Enterococcus faecium regulate type-2 inflammatory responses and modify the gut microbiota of pigs during helminth infection

This study examines how probiotic mixtures affect helminth infection and gut microbiota in pigs, finding that BBE modulates type-2 inflammation and microbiota but not infection levels.

Structure-function analysis of purified proanthocyanidins reveals a role for polymer size in suppressing inflammatory responses

This study shows that the size of proanthocyanidin polymers affects their ability to suppress inflammation in mice by modulating autophagy and gene pathways.

The phytonutrient cinnamaldehyde limits intestinal inflammation and enteric parasite infection

This study shows that cinnamaldehyde reduces intestinal inflammation and improves resistance to enteric parasite infection in mice, independent of gut microbiota.