M. E. Das

The Arp2/3 complex promotes periodic removal of Pak1-mediated negative feedback to facilitate anticorrelated Cdc42 oscillations.

This study shows that the Arp2/3 complex enables Pak1 removal through endocytosis, allowing Cdc42 reactivation and oscillations in S. pombe.

Cdc42 prevents precocious Rho1 activation during cytokinesis in a Pak1-dependent manner

This study shows that Cdc42 prevents early Rho1 activation during cytokinesis in fission yeast, ensuring proper timing of septum formation and cytokinesis fidelity through Pak1-dependent regulation.

Cdc42 GTPase activating proteins Rga4 and Rga6 coordinate septum synthesis and membrane trafficking at the division plane during cytokinesis

This study shows that Rga4 and Rga6 reduce Cdc42 activity during late cytokinesis to coordinate septum formation with membrane trafficking in fission yeast.

Cdc42 reactivation at growth sites is regulated by local cell-cycle-dependent loss of its GAP Rga4

The paper shows that Cdc42 reactivation at growth sites in fission yeast is controlled by the cell-cycle-dependent loss of its GAP Rga4.

Cdc42 GTPase Activating Proteins (GAPs) Maintain Generational Inheritance of Cell Polarity and Cell Shape in Fission Yeast

This study shows that Cdc42 GAP proteins Rga4 and Rga6 mediate generational inheritance of cell polarity and shape in fission yeast through asymmetric distribution during cell division.

Cdc42 promotes Bgs1 recruitment for septum synthesis and glucanase localization for cell separation during cytokinesis in fission yeast.

A novel interplay between GEFs orchestrates Cdc42 activation in cell polarity and cytokinesis

The paper identifies a crosstalk mechanism between Gef1 and Scd1 GEFs that spatially regulates Cdc42 activation to control cell polarity and cytokinesis in fission yeast.

F-BAR Cdc15 Promotes Gef1-mediated Cdc42 Activation During Cytokinesis and Cell Polarization in S. pombe

This study shows that Cdc15 promotes Gef1 localization to the division site and cell cortex to activate Cdc42, facilitating cytokinesis and bipolarity in S. pombe.