Astroglia proliferate upon biogenesis of tunneling nanotubes and clearance of α-synuclein toxicities
A. Raghavan, R. Kashyap, S. P, S. Jos, S. Chatterjee, A. Alex, M. N. D' Souza, M. Giridharan, R. Muddashetty, R. Manjithaya, S. Padavattan, S. Nath
This study shows that α-synuclein protofibrils induce tunneling nanotube biogenesis in astrocytes, which facilitates clearance of toxic aggregates and reversal of cellular senescence, leading to enhanced proliferation.
bioRxiv · Aug 24, 2023Cell Biology