S. Nath

Loss of FBXO31-mediated γH2AX foci formation impairs initiation of NHEJ and HR repair pathways, and sensitizes breast cancer to therapy

This study shows that FBXO31-mediated γH2AX foci formation is essential for DNA repair pathways and that its loss sensitizes breast cancer to chemotherapy.

Astroglia proliferate upon biogenesis of tunneling nanotubes and clearance of α-synuclein toxicities

This study shows that α-synuclein protofibrils induce tunneling nanotube biogenesis in astrocytes, which facilitates clearance of toxic aggregates and reversal of cellular senescence, leading to enhanced proliferation.

Targeting staphylococcal cell-wall biosynthesis protein FemX through steered molecular dynamics and drug-repurposing approach

This study repurposes FDA-approved drugs against S. aureus by analyzing their binding to FemX using SMD and shows Lumacaftor has higher affinity and lower toxicity.

Characterising replisome disassembly in human cells

This study characterizes replisome disassembly in human cells, showing that Cullin2, LRR1, and p97 are required, and that replication stress occurs with inhibitor treatment.

Assessment of local potato cultivars found in Cis-Himalayan region of West Bengal through morphology and biochemical profiling

This study evaluates local potato cultivars from North Bengal for morphology and anthocyanin content to identify stable genotypes with high tuber yield and antioxidant properties.

Amyloid-β induced membrane damage instigates tunneling nanotubes by exploiting PAK1 dependent actin remodulation

This study shows that amyloid-β oligomers induce tunneling nanotubes via PAK1-dependent actin remodeling and membrane repair mechanisms in neuronal cells.

Repression of MUC1 promotes expansion and suppressive function of myeloid-derived suppressor cells in pancreatic ductal adenocarcinoma and breast cancer murine models.

This study shows that MUC1 repression in MDSCs enhances their proliferation and suppressive function in pancreatic and breast cancer models, leading to increased tumor growth and immune suppression.

The Response of Bacterial Flagellar Motor to Stepwise Increase in NaCl Concentration

This study examines how increasing NaCl concentration affects the flagellar motor speed and switching rates in E. coli and Salmonella enteritidis, revealing significant changes in motor behavior under high osmolarity conditions.

Monomeric amyloid beta-peptide (1-42) significantly populates compact fibril-like conformations

This study uses molecular dynamics simulations to show that the Aβ42 monomer adopts a fibril-like conformation in solution, suggesting a potential role in amyloid aggregation.

Effect of cell size and tethering geometry on rotation rate and torque of E.coli cells

This study measures how cell size and tethering geometry affect the torque and rotation rate of E. coli flagellar motors.

Tumor -Associated MUC1 Regulates TGF-β Signaling and Function in Pancreatic Ductal Adenocarcinoma

This study shows that high tMUC1 expression in PDA correlates with altered TGF-β signaling, promoting tumor growth and resistance to TGF-β therapy.

The bacterial quorum sensing signal DSF hijacks Arabidopsis thaliana sterol biosynthesis to suppress plant innate immunity

This study shows that the bacterial QS molecule DSF suppresses Arabidopsis innate immunity by altering sterol biosynthesis and disrupting FLS2 receptor dynamics.

Dynamic actin-mediated nano-scale clustering of CD44 regulates its meso-scale organization at the plasma membrane

This study reveals that CD44 forms a meso-scale meshwork at the plasma membrane, regulated by actin dynamics and nano-scale clustering.