Author

A. Alex

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Organism:human· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

A. Musacchio· 2 shared V. Piano· 2 shared A. Joglekar· 1 shared A. Petrovic· 1 shared A. Raghavan· 1 shared B. Roy· 1 shared B. Voss· 1 shared C. Chen· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersCell Biology

A. Musacchio

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3 papers

Recent·Most cited

Astroglia proliferate upon biogenesis of tunneling nanotubes and clearance of α-synuclein toxicities

A. Raghavan, R. Kashyap, S. P, S. Jos, S. Chatterjee, A. Alex, M. N. D' Souza, M. Giridharan, R. Muddashetty, R. Manjithaya, S. Padavattan, S. Nath

This study shows that α-synuclein protofibrils induce tunneling nanotube biogenesis in astrocytes, which facilitates clearance of toxic aggregates and reversal of cellular senescence, leading to enhanced proliferation.

bioRxiv · Aug 24, 2023Cell Biology

The Structural Flexibility of MAD1 Facilitates the Assembly of the Mitotic Checkpoint Complex

C. Chen, V. Piano, A. Alex, S. Han, P. J. Huis in t Veld, B. Roy, A. Musacchio, A. Joglekar

This study shows that structural flexibility in MAD1's hinge region is crucial for efficient MCC assembly and SAC signaling, with implications for understanding mitotic checkpoint function.

bioRxiv · Jun 29, 2022 · PreprintCell Biology

Electroporated recombinant proteins as tools for in vivo functional complementation, imaging, and chemical biology

A. Alex, V. Piano, S. Polley, M. Stuiver, S. Voss, G. Ciossani, K. Overlack, B. Voss, S. Wohlgemuth, A. Petrovic, Y.-W. Wu, P. Selenko, A. Musacchio, S. Maffini

This study demonstrates that electroporation can deliver recombinant proteins into human cells, maintaining their localization, function, and interactions, making it a versatile tool for chemical and synthetic biology.

bioRxiv · May 8, 2019Cell Biology