A. Ram

Influenza A defective viral genomes and non-infectious particles are in-creased by host PI3K inhibition via anti-cancer drug alpelisib

This study shows that alpelisib, a PI3K inhibitor, increases defective viral genomes and particles in A/H3N2 but decreases total particles in A/H1N1, suggesting host metabolism influences viral defectiveness.

Finding needles in haystacks: identification of novel conserved PETase enzymes in Streptomyces

The paper identifies and analyzes three variants of lipase A from Streptomyces that show PET-degrading activity, with S2LipA demonstrating efficient degradation of BHET and PET films.

Oral Delivery of Kidney Targeting Nanotherapeutics for Polycystic Kidney Disease

This study develops an oral nanoparticle delivery system for metformin in ADPKD, showing improved kidney targeting and bioavailability compared to conventional methods.

LaeA-dependent production of small molecules of Aspergillus niger that compete with specific antibodies that bind to human immune receptors

The paper identifies small molecules secreted by Aspergillus species that compete with antibodies binding to human immune receptors, with LaeA regulating some of these molecules.

GPR171 Agonist Reduces Chronic Neuropathic and Inflammatory Pain in Male, but not in Female Mice

Reprogramming of the apoplast metabolome of Lolium perenne upon infection with the mutualistic symbiont Epichloë festucae

The paper investigates changes in the apoplast metabolome of Lolium perenne infected with Epichloë festucae, identifying novel metabolites and validating methods for their detection.