K. Jiang

Rapid protein evolution by few-shot learning with a protein language model

This paper introduces EVOLVEpro, a few-shot learning framework using protein language models to rapidly improve protein activity with minimal experimental data.

The GndA microprotein promotes cell growth during heat shock in Escherichia coli

This study identifies GndA, a microprotein in Escherichia coli, which promotes cell growth during heat shock independently of its overlapping 6PGD protein.

Electroadhesive hydrogel interface for prolonged mucosal theranostics

This paper develops e-GLUE, an electroadhesive hydrogel interface that enables prolonged mucosal retention and demonstrates its utility in GI theranostics.

Structure-based virtual screening identifies small molecule inhibitors of O-fucosyltransferase SPINDLY

The paper identifies SOFTI, a specific inhibitor of SPY O-fucosyltransferase, through virtual screening and validates its effects on O-fucosylation in Arabidopsis and tomato.

EB1 decoration of microtubule lattice facilitates spindle-kinetochore lateral attachment in Plasmodium male gametogenesis

This study identifies Plasmodium EB1's unique MT-lattice binding role in facilitating spindle-kinetochore lateral attachment during male gametogenesis, essential for proper chromosome segregation and parasite transmission.

Androgen aggravates aortic aneurysms via suppressing PD-1 in mice

This study shows androgen promotes aortic aneurysms in male mice by suppressing PD-1 in T cells, suggesting immune checkpoint therapy risks for patients with aortic aneurysm risk factors.

Oral Delivery of Kidney Targeting Nanotherapeutics for Polycystic Kidney Disease

This study develops an oral nanoparticle delivery system for metformin in ADPKD, showing improved kidney targeting and bioavailability compared to conventional methods.

The translational role of SOS1 in colorectal cancer

This paper investigates the role of SOS1 in colorectal cancer using patient-derived organoids and identifies SOS1 protein expression as a predictive marker for response to SOS1 inhibitors.

CAMSAP-driven microtubule release from γ-TuRC and its regulation by nucleation-promoting factors

This study investigates how CAMSAP proteins and CDK5RAP2 regulate microtubule release from γ-TuRC, revealing their roles in microtubule nucleation and stabilization.

Deleterious Mechanical Deformation Selects Mechanoresilient Cancer Cells with Enhanced Proliferation and Chemoresistance

The paper shows that mechanical deformation selects for cancer cells with enhanced proliferation and chemoresistance, linking physical microenvironmental barriers to metastatic malignancy.

Functional characterization of multidomain protein Vip3Aa from Bacillus thuringiensis reveals a strategy to increase its insecticidal potency

This study characterizes the functional domains of Vip3Aa protein from Bacillus thuringiensis and shows how modifying protease sites enhances its insecticidal potency against Spodoptera frugiperda larvae.

AIM1-dependent high basal SA accumulation modulates stomatal aperture in rice

This study identifies OsAIM1 as essential for high basal SA levels in rice, which regulate stomatal aperture and shoot temperature.

Chemical genetic screening identifies nalacin as an inhibitor of GH3 amido synthetase for auxin conjugation

The paper identifies nalacin as an inhibitor of GH3 amido synthetase, which regulates auxin conjugation in plants, with potential applications in agriculture and research.

Single-cell analysis reveals the range of transcriptional states of circulating human neutrophils

This study uses scRNA-seq to show that circulating human neutrophils are transcriptionally heterogeneous, forming four distinct clusters with distinct transcriptional states.

Dissolvable microgel-templated macroporous hydrogels for controlled cell assembly

This paper develops a method to create cell-laden macroporous hydrogels using dissolvable microgels, enabling controlled cell assembly and secretion of growth factors.

Microtubule plus-end regulation by centriolar cap proteins

The paper investigates how CP110 and CEP97 regulate microtubule plus-end dynamics and centriole biogenesis through direct interactions and synergistic effects.

Drag-and-drop genome insertion without DNA cleavage with CRISPR-directed integrases

PASTE enables efficient, programmable gene integration without DNA breaks, applicable for research, cell engineering, and gene therapy.

Sub-second multi-channel magnetic control of select neural circuits in behaving flies

This study demonstrates sub-second, multichannel neural stimulation in flies using magnetic nanoparticles and temperature-sensitive ion channels, improving the temporal resolution of magnetogenetics.

Novel epitopes of human monoclonal antibodies targeting the influenza virus N1 neuraminidase

This study identifies novel epitopes of human monoclonal antibodies targeting the influenza virus N1 neuraminidase and characterizes escape mutations and their impact on viral fitness.

Establishing a Living Biobank of Patient-Derived Organoids of Intraductal Papillary Mucinous Neoplasms of the Pancreas

This study establishes a living biobank of patient-derived organoids from intraductal papillary mucinous neoplasms to study their progression and identify biomarkers for early detection and prevention.

Controlled Release of Anti-inflammatory and Pro-angiogenic Factors from Macroporous Scaffolds

This study develops a dual-drug delivery scaffold using microbeads to locally release anti-inflammatory and pro-angiogenic agents, showing improved implant integration and vascularization.

Heterogeneity in collective endothelial cell behavior is a driver of arterio-venous remodeling

The paper identifies heterogeneous collective endothelial cell behaviors driving arterio-venous remodeling during vascular development in zebrafish.

Structural insights into the insecticidal Vip3A toxin of Bacillus thuringiensis

This study presents the first crystal structure of the Vip3A toxin, revealing its domain organization and glycan binding specificity, which informs its insecticidal mechanism and potential for improved bio-insecticides.

Cancer exosomes harbor diverse hypoxia-targeted mRNAs and contribute toward tumor angiogenesis

This study identifies hypoxia-targeted mRNAs in cancer exosomes that promote angiogenesis and reprogram recipient cells.

A general in vitro assay to study enzymatic activities of the ubiquitin system

The paper introduces a FRET-based assay to measure ubiquitination kinetics in vitro, demonstrating its versatility and compatibility with various enzyme combinations.

Structural determinants of microtubule minus end preference in CAMSAP CKK domains

This study compares human and Naegleria CKK domains to show how structural differences in tubulin conformations enable microtubule minus-end recognition.

Exploring the influence of surface proteins on probiotic activity of Lactobacillus pentosus HC-2 in Litopenaeus vannamei midgut via Label-free quantitative proteomic analysis

This study identifies surface proteins of Lactobacillus pentosus HC-2 as essential for its probiotic effects in shrimp midgut using proteomic analysis.

Triazole ureas covalently bind to strigolactone receptors and regulate signaling

This study identifies triazole urea compounds that covalently bind to strigolactone receptors, inhibiting their function and providing insights into SL signaling mechanisms.