Author

C. Poon

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 6 Immunology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:cell type annotation· 5 Organism:human· 4 Organism:mouse· 4 Research Focus:differential expression· 3 Research Focus:drug response / drug discovery· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:host-pathogen & immune response· 2

Frequent Co-Authors

D. Chin· 2 shared E. J. Chung· 2 shared J. Wang· 2 shared A. Daemen· 1 shared A. Hong· 1 shared A. K. Katakam· 1 shared A. N. Lima· 1 shared A. Plotkin· 1 shared

Activity by Year

2020-2023 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersBioengineering

D. Chin

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Spatially resolved single-cell analysis uncovers protein kinase C-& expressing microglia with anti-tumor activity in glioblastoma

R. Mirzaei, R. McNeil, C. D'Mello, B. Wong, S. Sarkar, F. Visser, C. Poon, P. Bose, V. W. Yong

This study identifies PKCδ-expressing microglia with anti-tumor activity in GBM using spatial transcriptomics and confirms their presence in human samples.

bioRxiv · Dec 4, 2023 · PreprintImmunology

Myeloid-specific KDM6B inhibition sensitizes Glioblastoma to PD1 blockade

S. Goswami, D. Raychaudhuri, P. Singh, S. M. Natarajan, Y. Chen, C. Poon, M. Hennessey, J. Zhang, S. Anandhan, B. P. Kerrigan, M. D. Macaluso, Z. He, S. Jindal, F. F. Lang, S. Basu, P. Sharma

This study shows that inhibiting KDM6B in myeloid cells improves response to PD1 blockade in glioblastoma by enhancing anti-tumor immunity.

Nature Cancer · Aug 31, 2023Peer-reviewedImmunology

Oral Delivery of Kidney Targeting Nanotherapeutics for Polycystic Kidney Disease

Y. Huang, J. Wang, D. Chin, V. Mancino, J. Pham, H. Li, K. Jiang, A. Ram, C. Poon, P.-Y. Ho, J. Peti-Peterdi, G. Gyarmati, K. R. Hallows, E. J. Chung

This study develops an oral nanoparticle delivery system for metformin in ADPKD, showing improved kidney targeting and bioavailability compared to conventional methods.

bioRxiv · Oct 18, 2022 · PreprintBioengineering

A simple method of suspending implant wear particles for more physiological modelling of cell-particle interactions in vitro

C. Poon

This study introduces a method using sodium methylcellulose to suspend implant wear particles in culture media, enabling more realistic in vitro modeling of cell-particle interactions.

bioRxiv · Jan 5, 2021 · PreprintBioengineering

Quantification of Hypoperfusion in Autism Assessed by Diffuse Correlation Spectroscopy and Frequency Domain Near Infrared Spectroscopy

B. Rinehart, C. Poon, U. Sunar

This study uses DCS to quantify hypoperfusion in an autism model, finding significantly lower blood flow in autistic group compared to controls.

bioRxiv · Nov 5, 2020Bioengineering

Nanoparticle-mediated microRNA-145 Delivery for Vascular Smooth Muscle Cell Phenotype Modulation and Atherosclerosis Treatment

D. Chin, C. Poon, J. Wang, J. Joo, V. Ong, Z. Jiang, K. Cheng, A. Plotkin, G. A. Magee, E. J. Chung

This study develops miR-145-loaded nanoparticles to target VSMC phenotype switching and atherosclerosis, showing reduced plaque growth and restored contractile markers in vitro and in mice.

bioRxiv · Sep 9, 2020 · PreprintBioengineering

Measuring the density and viscosity of culture media for optimized computational fluid dynamics analysis of in vitro devices

C. Poon

This study measures the density and viscosity of culture media with and without fetal bovine serum to improve computational fluid dynamics modeling of in vitro systems.

bioRxiv · Aug 25, 2020 · PreprintBioengineering

Biomimetic system design for engineering biofidelic 3-D respiratory tissues in vitro

C. Poon, M. Zhang, P. Boughton, A. Hong, A. Ruys

This paper introduces a biomimetic system for culturing 3-D respiratory tissues under physiological strain and air-liquid interface conditions, showing improved cell distribution and density compared to static controls.

bioRxiv · Jun 25, 2020 · PreprintBioengineering

G9a methyltransferase governs cell identity in the lung and is required for KRAS G12D tumor development and propagation

A. Pribluda, A. Daemen, A. N. Lima, X. Wang, M. Hafner, C. Poon, Z. Modrusan, A. K. Katakam, O. Foreman, J. Eastham, J. Hung, B. Haley, J. T. Garcia, E. L. Jackson, M. R. Junttila

This study shows G9a methyltransferase regulates Wnt signaling in lung development and tumor progression by controlling β-catenin transcriptional activity, and its inhibition prevents KrasG12D lung cancer.

bioRxiv · Apr 20, 2020 · PreprintCancer Biology