J. Pham

YAP dysregulation triggers hypertrophy by CCN2 secretion and TGFβ uptake in human pluripotent stem cell-derived cardiomyocytes

This study shows that YAP overactivation in HCM mutant cardiomyocytes drives hypertrophy via CCN2 secretion and TGFβ uptake.

Histologic variants in bladder cancer harbor aggressive molecular features including TM4SF1 expression and a CA125+ cell state

Single cell RNA sequencing of bladder cancer subtypes identified a CA125+ cell state linked to aggressive features and TM4SF1 as a therapeutic target.

Accelerated Hematopoietic Stem Cell Aging in Space

This study shows spaceflight accelerates hematopoietic stem cell aging through molecular changes like reduced dormancy and mutagenesis, suggesting potential for prevention.

Urothelium-specific expression of mutationally activated Pik3ca initiates early lesions of non-invasive bladder cancer

This study creates a mouse model to study PIK3CA mutations in bladder cancer, showing early tumorigenic changes but no progression to invasion without additional genetic factors.

mini-MEndR: A 96-well mixed species assay to co-evaluate human and mouse Pax7+ cell-mediated skeletal muscle repair

The paper introduces a 96-well mini-MEndR assay to co-evaluate human and mouse Pax7+ cell-mediated skeletal muscle repair, demonstrating its utility for drug screening and phenotypic analysis.

Oral Delivery of Kidney Targeting Nanotherapeutics for Polycystic Kidney Disease

This study develops an oral nanoparticle delivery system for metformin in ADPKD, showing improved kidney targeting and bioavailability compared to conventional methods.

Beneficial Effects of Bempedoic Acid Treatment in Polycystic Kidney Disease Cells and Mice

This study shows that bempedoic acid reduces cyst growth in ADPKD cells and mice, and combining it with tolvaptan enhances therapeutic effects.

Plasmodium-encoded murine IL-6 impairs liver stage infection and elicits long-lasting sterilizing immunity

This study shows that Plasmodium parasites engineered to express murine IL-6 fail to progress to blood stage infection and induce long-lasting CD8+ T cell-mediated immunity.

Profiling Human CMV-specific T cell responses reveals novel immunogenic ORFs

The paper identifies 235 unique HCMV-specific T cell epitopes, including 41 from recently described novel ORFs, revealing a broader T cell response to HCMV than previously known.

Evolutionary tracking of cancer haplotypes at single-cell resolution

The paper tracks cancer haplotypes at single-cell resolution, revealing allele-specific alterations and their role in structural variation evolution in human tumors.

The impact of mutational processes on structural genomic plasticity in cancer cells

The paper analyzes structural genomic variations in cancer cells to understand how mutational processes influence cell-to-cell genomic diversity and tumor evolution.

Transcriptional analysis of peripheral memory T cells reveals Parkinson's disease-specific gene signatures

The paper identifies PD-specific gene signatures in peripheral memory T cells by analyzing RNA-seq data from PD patients and healthy controls.

Effect of chronic JUUL aerosol inhalation on inflammatory states of the brain, lung, heart and colon in mice

Chronic JUUL aerosol inhalation in mice alters inflammatory states in brain, lung, heart, and colon, with flavor-dependent effects and potential long-term health risks.

Single cell fitness landscapes induced by genetic and pharmacologic perturbations in cancer

This study develops a quantitative fitness model to analyze clonal dynamics in cancer under genetic and pharmacologic perturbations, revealing how mutations and drug resistance shape tumor evolution.

A novel luminescence-based β-arrestin membrane recruitment assay for unmodified GPCRs

This paper introduces a luminescence-based assay to measure arrestin recruitment to unmodified GPCRs, avoiding C-terminal modifications.

Development of Inflammatory Bowel Disease is Linked to a Longitudinal Restructuring of the Gut Metagenome in Mice

This study uses longitudinal metagenomic analysis in a mouse model of IBD to identify microbial functional changes linked to disease progression and immune activation.