Fibroblast State Reversal By MBNL1-Dependent Transcriptome Modification Regulates Cardiac Repair
D. Bugg, R. Bretherton, K. Beach, A. Reese, J. Gunaje, G. Flint, C. A. DeForest, A. Stempien-Otero, J. Davis
This study shows that MBNL1 regulates fibroblast state transitions in cardiac repair, with overexpression preventing fibrosis and loss reverting cells to a progenitor state.
bioRxiv · Jan 26, 2021 · PreprintCell Biology