Author

D. Bugg

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

J. Davis· 3 shared J. Gunaje· 3 shared C. A. DeForest· 2 shared G. Flint· 2 shared I. M. Reichardt· 2 shared L. R. J. Bailey· 2 shared M. Regnier· 2 shared N. J. Sniadecki· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersCell Biology

J. Davis

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Author profile →

4 papers

Recent·Most cited

MBNL1 regulates programmed postnatal switching between regenerative and differentiated cardiac states.

L. R. J. Bailey, D. Bugg, I. M. Reichardt, C. D. Ortac, J. Gunaje, R. Johnson, M. J. MacCoss, T. Sakamoto, D. P. Kelly, M. Regnier, J. M. Davis

This study identifies MBNL1 as a regulator of cardiac cell state transitions, showing it controls RNA stability to switch between regenerative and differentiated states.

bioRxiv · Mar 16, 2023Cell Biology

Correcting dilated cardiomyopathy with fibroblast-targeted p38 deficiency

R. C. Bretherton, I. M. Reichardt, K. A. Zabrecky, A. J. Goldstein, L. R. J. Bailey, D. Bugg, T. S. McMillen, K. B. Kooiker, G. Flint, A. Martinson, J. Gunaje, F. Koser, W. A. Linke, M. Regnier, F. Moussavi-Harami, , J. Davis

This study shows that targeting p38 in cardiac fibroblasts can reverse fibrosis and improve cardiomyocyte function in a mouse model of dilated cardiomyopathy.

bioRxiv · Jan 23, 2023 · PreprintCell Biology

Fibroblast State Reversal By MBNL1-Dependent Transcriptome Modification Regulates Cardiac Repair

D. Bugg, R. Bretherton, K. Beach, A. Reese, J. Gunaje, G. Flint, C. A. DeForest, A. Stempien-Otero, J. Davis

This study shows that MBNL1 regulates fibroblast state transitions in cardiac repair, with overexpression preventing fibrosis and loss reverting cells to a progenitor state.

bioRxiv · Jan 26, 2021 · PreprintCell Biology

Engrafted Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Undergo Clonal Expansion In Vivo

D. El-Nachef, D. Bugg, K. M. Beussman, A. M. Martinson, C. E. Murry, N. J. Sniadecki, J. Davis

The paper uses a fluorescent barcoding system to track clonal expansion of engrafted hPSC-CMs in vivo, finding that some cells proliferate while others hypertrophy without dividing.

bioRxiv · Nov 20, 2019Cell Biology