Author

L. Prince

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Biophysics· 1 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:zebrafish· 4 Organism:human· 2 Assay:imaging· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

S. Renshaw· 3 shared A. M. Condliffe· 2 shared K. A. Bowden· 2 shared Y. X. Ho· 2 shared A. A. R. Thompson· 1 shared A. Bernut· 1 shared A. Cadby· 1 shared A. J. Cadby· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersCell Biology

S. Renshaw

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Pulses of Class I PI3kinase activity identify the release and recapture of prey from neutrophil phagosomes

C. F. Muir, C. C. Reyes-Aldasoro, F. Ellett, T. Prajsnar, Y. X. Ho, A. Bernut, C. A. Loynes, S. Elworthy, K. A. Bowden, A. J. Cadby, L. Prince, J. S. King, A. M. Condliffe, S. Renshaw

The paper identifies pulsatile Class I PI3K activity on neutrophil phagosomes during bacterial infection, suggesting phagosomes reopen and reclose to release or restart digestion.

bioRxiv · Feb 29, 2024 · PreprintCell Biology

Candida spp. suppress neutrophil reactive nitrogen species to evade killing

T. B. Burgess, F. R. Hammond, P. T. Szkuta, A. Lewis, S. Christou, K. A. Bowden, T. Bicanic, L. Prince, K. R. Ayscough, D. G. Partridge, S. A. Johnston, A. M. Condliffe, P. M. Elks

This study shows that Candida spp. suppress neutrophil reactive nitrogen species to evade killing, and restoring RNS via Hif-1 stabilisation improves infection outcomes.

bioRxiv · Nov 2, 2023Immunology

Determining the importance of the stringent response for methicillin-resistant Staphylococcus aureus virulence using a zebrafish model of infection

N. R. Choudhury, L. Urwin, B. Salamaga, L. Prince, S. Renshaw, R. M. Corrigan

This study uses a zebrafish model to show that the stringent response, mediated by (p)ppGpp synthetases, is critical for S. aureus virulence and survival within host phagocytes.

bioRxiv · Jul 12, 2023 · PreprintMicrobiology

Multi-modal imaging reveals dynamic interactions of Staphylococcus aureus within human neutrophils

Y. X. Ho, E. Steele, L. Prince, A. Cadby

This study uses multi-modal imaging to observe dynamic interactions of Staphylococcus aureus within human neutrophils, revealing binary fission of the bacteria inside the cells.

bioRxiv · Mar 5, 2021 · PreprintBiophysics

Inhibition of ErbB kinase signalling promotes resolution of neutrophilic inflammation

L. Prince, S. Renshaw, A. Rahman, K. M. Henry, K. Herman, A. A. R. Thompson, H. Isles, C. Tulotta, D. Sammut, J. Rougeot, N. Khoshaein, A. Reese, K. Higgins, C. Tabor, I. Sabroe, , D. Dockrell

The paper identifies ErbB kinase inhibitors as potential therapies for neutrophilic inflammation by showing they accelerate neutrophil apoptosis in multiple models.

bioRxiv · Aug 19, 2019Immunology