Temporal dynamics and genomic programming of plasma cell fates
G. K. M. Vijay, M. Zhou, K. Thakkar, A. Rothrauff, A. Chawla, D. Chen, L. Lau, P. Habib, K. Chetal, P. Chhibbar, J. Fan, J. Das, A. V. Joglekar, L. Borghesi, N. Salomonis, , H. Singh
This study identifies a novel PC transition state and shows that long-lived plasma cells arise from late-phase GC responses through TIGIT-dependent clonal expansion.
bioRxiv · Aug 27, 2023 · PreprintImmunology