H. Singh

Combining Scalable Organ Chip Platform with Deep Learning-Based Imaging Analysis for Cancer Therapeutic Screening

The paper combines an organ chip platform with deep learning for drug response analysis in cancer models, showing improved accuracy over traditional methods.

Targeting mitochondrial metabolism with CPI-613 in chemoresistant ovarian tumors

This study shows CPI-613 reduces tumor growth in chemoresistant ovarian tumors by inhibiting mitochondrial function and enhancing chemotherapy response.

Heat Stable and Intrinsically Sterile Liquid Protein Formulations

This paper develops non-aqueous, fluorine-based liquid protein formulations that are thermally stable and sterile, reducing reliance on cold chain logistics.

Expression of Plasmodium Major Facilitator Superfamily Protein in Transporters-Delta Candida Identifies a Drug Transporter

The paper assesses the functional relevance of a Plasmodium MFS protein as a drug transporter using Candida glabrata, showing antifungal resistance and antimalarial properties.

Conformational Dynamics and metal-ion interactions in human small Ubiquitin-like modifier (SUMO2)

This study investigates Cu2+ ion binding and conformational flexibility in SUMO2, showing its impact on aggregation and non-covalent interactions with SIMs.

Development and Outcomes of an International Certificate Program in Science Policy and Advocacy for STEM PhD Students and Postdocs

The paper describes an international certificate program in science policy and advocacy for STEM PhD students and postdocs, showing it helped participants transition into policy roles and careers.

2-bromo-2',5'-dihydroxychalcone analogue Inhibits Endothelial Migration by Targeting VEGF-induced ERK 1/2 Phosphorylation

This paper evaluates a 2-bromo-2',5'-dihydroxychalcone analogue (AH9) for its ability to inhibit endothelial cell migration by blocking VEGF-induced ERK1/2 phosphorylation, showing comparable efficacy to Sorafenib.

Temporal dynamics and genomic programming of plasma cell fates

This study identifies a novel PC transition state and shows that long-lived plasma cells arise from late-phase GC responses through TIGIT-dependent clonal expansion.

Rapid Prototyping of Thermoplastic Microfluidic 3D Cell Culture Devices by Creating Regional Hydrophilicity Discrepancy

This paper develops a method to rapidly prototype thermoplastic microfluidic devices for 3D cell culture by creating regional hydrophilicity discrepancies, enabling dynamic cell culture and drug screening.

Overcoming migratory exhaustion: Expression of Matrix metalloproteinase-8 (MMP-8) promotes tumor infiltration and anti-tumor activity of CAR-T cells

This study shows that CAR-T cells engineered to secrete MMP-8 enhance tumor infiltration and anti-tumor activity in solid tumors.

Replicative stress in gastroesophageal adenocarcinoma is associated with chromosomal instability and sensitivity to DNA damage response inhibitors.

The paper identifies DDR biomarkers and ploidy abnormalities in GEA that predict sensitivity to DDR inhibitors and premalignant progression.

Intermittent Fasting induced ketogenesis inhibits mouse epithelial ovarian tumors by promoting anti-tumor T cell response.

This study shows that intermittent fasting inhibits mouse epithelial ovarian tumors by enhancing anti-tumor T cell responses through metabolic changes and immune modulation.

Heritability and pre-adult survivorship costs of ectoparasite resistance in the naturally occurring Drosophila-Gamasodes mite system

This study shows that ectoparasite resistance in Drosophila can be selectively improved, but comes with a cost in pre-adult survivorship under stress.

Diagnostic tool to identify and treat DNA repair deficient gastroesophageal adenocarcinomas

This study identifies HR and NER deficiencies in gastric and esophageal adenocarcinomas and shows their responsiveness to platinum chemotherapy and PARP inhibitors.

T-cell potential for CD19-expressing malignancies revealed by multi-dimensional single-cell profiling

The paper identifies migration as a cell-intrinsic biomarker for CAR+ T cell efficacy in B-cell malignancies using multi-dimensional single-cell profiling.

miRNA408 and its encoded peptide, miPEP408, regulate arsenic stress response in Arabidopsis

miR408 and its encoded peptide miPEP408 regulate arsenic stress and low sulphur responses in Arabidopsis.

Persistent Immune and Clotting Dysfunction Detected in Saliva and Blood Plasma after COVID-19

The paper identifies persistent immune and clotting dysfunction in saliva and plasma of COVID-19 patients 4-6 weeks post-symptom resolution, highlighting saliva as a viable alternative to plasma for monitoring immune and inflammatory sequelae.

Multidimensional single-cell analysis identifies a role of CD2-CD58 interactions for clinical antitumor T cell responses

This study identifies CD2-CD58 interactions as critical for CAR T cell persistence and antitumor responses in lymphoma patients.

Antibodies targeting conserved non-canonical antigens and endemic coronaviruses associate with favorable outcomes in severe COVID-19

The paper identifies antibody responses against non-canonical and endemic coronavirus antigens as predictors of favorable outcomes in severe COVID-19.

Mutation in shoot-to-root mobile transcription factor, ELONGATED HYPOCOTYL 5, leads to low nicotine levels in tobacco

This study shows that mutation in the shoot-to-root mobile transcription factor NtHY5 reduces nicotine levels in tobacco by down-regulating the biosynthetic pathway in root tissues.

Inhibition of BKCa channels protects neonatal hearts against myocardial ischemia and reperfusion injury

This study shows that inhibiting BKCa channels in neonatal cardiomyocytes protects against myocardial ischemia-reperfusion injury, unlike in adult hearts where activation provides protection.

PRMT5 promotes symmetric dimethylation of RNA processing proteins and modulates activated T cell alternative splicing and Ca2+/NFAT signaling

This study identifies PRMT5's role in modulating alternative splicing and Ca2+/NFAT signaling in activated T cells through symmetric dimethylation of RNA processing proteins.

Auxin-responsive (phospho)proteome analysis reveals regulation of cell cycle and ethylene signaling during rice crown root development

Understanding distribution and occupancy of Himalayan Monal in Uttarkashi district, Uttarakhand

This study estimates the occupancy and abundance of Himalayan Monal in Uttarkashi district using camera traps and sign surveys, finding higher abundance outside protected areas.

Bifurcated monocyte states are predictive of mortality in severe COVID-19

The paper identifies bifurcated monocyte states in severe COVID-19 patients that predict mortality, with distinct cytokine and interferon gene modules associated with survival or death.

Measuring effects of trainee professional development on research productivity: A cross-institutional meta-analysis

This study analyzes the impact of professional development programs on doctoral students' research productivity and time to degree across ten institutions, finding no negative effects and some positive correlations.

Mutational signatures in countries affected by SARS-CoV-2: Implications in host-pathogen interactome

The paper analyzes 25k SARS-CoV-2 genomes to identify geographic mutations and their implications for host-pathogen interactions and vaccine efficacy.

Antibiofilm activity of Fmoc-phenylalanine against Gram-positive and Gram-negative bacterial biofilms

This study evaluates the antibiofilm activity of Fmoc-phenylalanine and other Fmoc-amino acids against Gram-positive and Gram-negative bacteria, showing inhibition and eradication of biofilms and synergistic effects with antibiotics.

Nutritional Immunity and Antibiotic Drug Treatments Influence Microbial Composition but Fail to Eliminate Urethral Catheter Biofilms in Recurrently Catheterized Patients

The study examines microbial dynamics and host interactions in urethral catheter biofilms, showing antibiotic treatments alter composition but fail to eliminate biofilms.

Genomic programming of antigen cross-presentation in IRF4-expressing human Langerhans cells

The paper identifies IRF4 as a key transcription factor driving antigen cross-presentation in human Langerhans cells, distinguishing them from conventional dendritic cells.