BiochemistrybioRxiv
Structure-guided enhancement of selectivity of chemical probe inhibitors targeting bacterial seryl-tRNA synthetase
R. Cain, R. Salimaraj, A. S. Punekar…·D. I. Roper
The paper identifies small molecule inhibitors that selectively target bacterial seryl-tRNA synthetases over human homologues using structure-based drug discovery.
DOI 10.1021/acs.jmedchem.9b01131