Cancer BiologybioRxivPreprint
CHA1: A New Combinatorial Therapy That Reciprocally Regulates Wnt and JAK/STAT/Interferon Signaling to Re-program Breast Tumors and the Tumor-Resident Landscape.
M. K. Alamoudi, M. E. Chipman, F. H. Deleso-Frechette…·A. S. Yee
CHA1, a combination of EGCG and decitabine, reprograms TNBC tumors and their microenvironment by inhibiting Wnt and activating JAK/STAT/IFN signaling, enhancing PD-L1 expression and T-cell infiltration.
DOI 10.1101/2022.03.25.485706