A. J. Lee

An image segmentation pipeline optimized for human microglia uncovers sources of morphological diversity in Alzheimer's disease

This study develops an image segmentation pipeline to analyze human microglia morphology in Alzheimer's disease, revealing that microglia associated with amyloid plaques have distinct morphological features.

Psychosocial experiences are associated with human brain mitochondrial biology

This study links psychosocial experiences to mitochondrial biology in the human brain, finding positive experiences correlate with higher OxPhos machinery abundance and negative experiences with lower abundance.

The subacromial bursa is a key regulator of the rotator cuff and a new therapeutic target for improving repair

The paper shows that the subacromial bursa is activated by rotator cuff injury and regulates the paracromal environment to maintain tendon and bone properties, suggesting it should be retained for better healing.

Volumetric refractive index measurement and quantitative density analysis of mouse brain tissue with sub-micrometer spatial resolution

This paper presents a label-free method for high-resolution volumetric imaging and analysis of mouse brain tissue with sub-micrometer spatial resolution.

Expression and functional evaluation of recombinant human ABO blood group antigen cleaving glycoside hydrolases α-N-acetylgalactosaminidase, α-galactosidase, and endo-β-galactosidase produced in Escherichia coli

This study evaluates recombinant glycoside hydrolases for converting A, B, and AB blood types to O by cleaving surface antigens, showing partial success in porcine red blood cells.

CHA1: A New Combinatorial Therapy That Reciprocally Regulates Wnt and JAK/STAT/Interferon Signaling to Re-program Breast Tumors and the Tumor-Resident Landscape.

CHA1, a combination of EGCG and decitabine, reprograms TNBC tumors and their microenvironment by inhibiting Wnt and activating JAK/STAT/IFN signaling, enhancing PD-L1 expression and T-cell infiltration.

Computationally efficient assembly of a Pseudomonas aeruginosa gene expression compendium

The paper processes and normalizes thousands of Pseudomonas aeruginosa RNA-seq datasets to enable cross-experiment comparisons and hypothesis testing.

Three-Dimensional Label-Free Imaging and Quantification of Migrating Cells during Wound Healing

This paper introduces a label-free 3D imaging method for wound healing assays, enabling quantitative analysis of cell migration dynamics without exogenous labels.

Pseudomonas aeruginosa lasR mutant fitness in microoxia is supported by an Anr-regulated oxygen-binding hemerythrin

This paper identifies an Anr-regulated hemerythrin, Mhr, that enhances fitness of Pseudomonas aeruginosa lasR mutants in microoxic conditions by binding oxygen.

No evidence that inbreeding avoidance is up-regulated during the ovulatory phase of the menstrual cycle

The study investigates whether women's preference for male kin decreases during the ovulatory phase, finding no evidence to support this hypothesis.

Facial masculinity is only weakly correlated with handgrip strength in young adult women

This study examines the correlation between facial masculinity and handgrip strength in young women, finding only weak associations.

No compelling evidence that more physically attractive young adult women have higher estradiol or progesterone

The paper investigates the relationship between salivary estradiol and progesterone levels and physical attractiveness in women, finding no significant associations.

Hormonal correlates of pathogen disgust: Testing the Compensatory Prophylaxis Hypothesis

The paper tests the Compensatory Prophylaxis Hypothesis by examining correlations between hormonal changes and pathogen disgust in women, finding no support for the hypothesis.