BioengineeringbioRxivPreprint
Competitive, connective and allosteric Nanobodies that modulate the SOS1-RAS protein-protein interactions and tune the nucleotide exchange rate as a starting point for drug design
B. Fischer, T. Uchanski, A. Sheryazdanova…·J. Steyaert
The paper introduces methods to discover Nanobodies that modulate SOS1-RAS interactions and nucleotide exchange rates, with potential applications in drug design.
DOI 10.1101/2022.12.06.519258