Tubular Mitochondrial Pyruvate Carrier Disruption Elicits Redox Adaptations that Protect from Acute Kidney Injury
A. Rauckhorst, G. V. Martinez, G. M. Andrade, H. Wen, J. Y. Kim, A. Simoni, K. A. Mapuskar, P. Rastogi, E. J. Steinbach, M. L. McCormick, B. G. Allen, A. R. Jackson, N. S. Pabla, M. C. Coleman, D. R. Spitz, , D. Zepeda-Orozco
The paper shows that reducing mitochondrial pyruvate carrier activity in kidney tubular cells protects against acute kidney injury by enhancing redox defenses and survival.
bioRxiv · Jan 31, 2023Biochemistry