H. Wen

Wave succession in the pandemic clone of Vibrio parahaemolyticus driven by gene loss

The paper investigates gene loss in Vibrio parahaemolyticus pandemic clones, showing it drives wave succession through environmental and transmission advantages.

SARS-CoV-2 B Epitope-Guided Neoantigen NanoVaccines Enhance Tumor-Specific CD4/CD8 T Cell Immunity Through B Cell Antigen Presentation

This study develops a neoantigen vaccine using SARS-CoV-2 B cell epitopes to enhance CD4/CD8 T cell immunity through B cell antigen presentation, showing improved efficacy in multiple cancer models.

Single-Cell and Spatial Transcriptomic Analyses Deciphering the Three-Layer Architecture of Human Tuberculosis Granulomas

This study uses single-cell and spatial transcriptomics to analyze human tuberculosis granulomas, revealing a three-layer structure and identifying potential therapeutic targets.

Pressorum Sensing: Growth-induced Compression Activates cAMP Signaling in Pseudomonas aeruginosa

This paper introduces pressorum sensing in Pseudomonas aeruginosa, showing mechanical compression triggers cAMP signaling via the Pil-Chp system, leading to increased virulence.

Elasticity and Thermal Stability are Key Determinants of Hearing Rescue by Mini-Protocadherin-15 Proteins

The paper identifies elasticity and thermal stability as critical factors determining the effectiveness of mini-protocadherin-15 proteins in rescuing hearing in USH1F mouse models.

The Generalized Haldane (GH) model tracking population size changes and resolving paradoxes of genetic drift

The paper integrates the Wright-Fisher and Haldane models to resolve paradoxes in genetic drift by defining it through variance in transmission success rather than population size.

Dual Targeting of STING and PI3Kγ Eliminates Regulatory B Cells to Overcome STING Resistance for Pancreatic Cancer Immunotherapy

This paper develops a dual-targeting compound that eliminates regulatory B cells and overcomes STING resistance in pancreatic cancer, improving immunotherapy outcomes.

Inhibition of O-GlcNAc transferase activates type I interferon-dependent antitumor immunity by bridging cGAS-STING pathway

This study shows that inhibiting OGT activates type I interferon-dependent antitumor immunity by enhancing the cGAS-STING pathway through genomic instability.

The paradox of extremely fast evolution driven by genetic drift in multi-copy gene systems

The paper uses the GH model to analyze genetic drift in mammalian rDNA genes, finding that fixation times are faster than expected, suggesting stronger drift or adaptive evolution.

Photosynthetic living fibers fabrication from algal-bacterial consortia with controlled spatial distribution

This paper develops a co-culture platform to create photosynthetic living fibers using algal-bacterial consortia with controlled spatial distribution for bioremediation and advanced materials.

Tubular Mitochondrial Pyruvate Carrier Disruption Elicits Redox Adaptations that Protect from Acute Kidney Injury

The paper shows that reducing mitochondrial pyruvate carrier activity in kidney tubular cells protects against acute kidney injury by enhancing redox defenses and survival.

Investigation of a mathematical model describing global cancer growth and treatment: An inhomogeneous model based on the generalized logistic equation

This paper introduces an inhomogeneous mathematical model based on the generalized logistic equation to describe tumor growth and treatment, validated against clinical observations and theories of tumor heterogeneity.

Complex functional phenotypes of NMDA receptor disease variants

This study investigates how specific NMDA receptor variants affect receptor function through molecular dynamics and electrophysiology, revealing that altered interactions at P552 and F652 lead to complex functional deficits.

A common mechanism of temperature-sensing in thermoTRP channels

This study identifies a common mechanism for temperature sensing in TRPM8 and TRPV1 thermoTRP channels through water-protein interaction changes.

Mitochondrial Network Configuration Influences Sarcomere and Myosin Filament Structure in Striated Muscles

The paper shows mitochondrial network configuration affects sarcomere and myosin filament structure in striated muscles across species.

The runaway evolution of SARS-CoV-2 leading to the highly evolved Delta strain

This paper analyzes the evolution of SARS-CoV-2 through multiple strain waves, showing increasing mutations and suggesting a feedback loop between viral population size and mutation accumulation leading to the Delta strain.

Effects of short-term salinity exposure on haemolymph osmolality, gill morphology and Na+/K+ - ATPase activity in Solenaia oleivora

This study examines the physiological responses of Solenaia oleivora to short-term salinity exposure, showing changes in hemolymph osmolality, protein and amino acid concentrations, ion levels, and gill morphology.

One viral sequence for each host? - The neglected within-host diversity as the main stage of SARS-CoV-2 evolution

The paper shows that SARS-CoV-2 exhibits substantial within-host genetic diversity, challenging the assumption of low diversity per infected individual and highlighting the importance of studying evolution within hosts.

Microbial tryptophan catabolism affects the vector competence of Anopheles

This study shows that gut microbiota in Anopheles stephensi affects tryptophan metabolism, with Pseudomonas alcaligenes reducing 3-HK to protect against Plasmodium infection.

Landscape of glioblastoma niches reveals the prognostic effects of tumor-infiltrating cells

This study identifies prognostic non-tumor cell types in glioblastoma by analyzing gene expression across four cohorts, revealing risk and protective factors associated with immune response clusters.

Identification of four linear B-cell epitopes on the SARS-CoV-2 spike protein able to elicit neutralizing antibodies

The paper identifies four linear B-cell epitopes on the SARS-CoV-2 spike protein that can elicit neutralizing antibodies in multiple species.

Many are called but few are chosen - Multiple clonal origins greatly elevate the functional heterogeneity of tumors

The paper shows that tumors can have multiple clonal origins, leading to high functional heterogeneity, with some tumors containing 13 independent clones and others having a dominant clone with minor patches.

Sex, fitness decline and recombination - Muller's ratchet vs. Ohta's ratchet

The paper compares Muller's ratchet and Ohta's ratchet, finding that recombination may not significantly slow fitness decline in most parameter spaces.

Cross-subunit Interactions that Stabilize Open States Mediate Gating in NMDA Receptors

The paper identifies a cross-subunit interaction in NMDA receptors that stabilizes open states and slows current decay, linking it to pathogenic variants.

Investigating dual Ca2+ modulation of the ryanodine receptor 1 by molecular dynamics simulation

This study uses molecular dynamics simulations to investigate how Ca2+ binding modulates RyR1 activation and inhibition, revealing structural and dynamic changes associated with these processes.

Mutations beget more mutations - The baseline mutation rate and runaway accumulation

This paper proposes a runaway mutation model explaining how mutator mutations can lead to escalating mutation rates in both germline and somatic tissues, affecting evolutionary strategies across species.

Molecular evolution in large steps - Codon substitutions under positive selection

The paper shows that positive selection drives amino acid substitutions with large chemical property changes, while negative selection favors smaller changes, suggesting distinct evolutionary mechanisms.

Mechanisms of gene death in the Red Queen race revealed by the analysis of de novo microRNAs

The paper investigates how de novo microRNAs in Drosophila affect male fitness and reveals that adaptive de novo genes may die due to canceling fitness effects, suggesting quasi-neutrality and ongoing period-specific adaptations.